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Targeting LKB1 in cancer – exposing and exploiting vulnerabilities
The LKB1 tumour suppressor is a serine/threonine kinase that functions as master regulator of cell growth, metabolism, survival and polarity. LKB1 is frequently mutated in human cancers and research spanning the last two decades have begun decoding the cellular pathways deregulated following LKB1 in...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4647688/ https://www.ncbi.nlm.nih.gov/pubmed/26196184 http://dx.doi.org/10.1038/bjc.2015.261 |