Cargando…
Patient-reported outcomes during and after definitive chemoradiotherapy for oesophageal cancer
BACKGROUND: Limited data describe patient-reported outcomes (PROs) of localised oesophageal cancer treated with definitive chemoradiotherapy(CRT). The phase 2/3 SCOPE-1 trial assessed the effectiveness of CRT±cetuximab. The trial for the first time provided an opportunity to describe PROs from a mul...
Autores principales: | , , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4647690/ https://www.ncbi.nlm.nih.gov/pubmed/26203761 http://dx.doi.org/10.1038/bjc.2015.258 |
_version_ | 1782401154745892864 |
---|---|
author | Rees, J Hurt, C N Gollins, S Mukherjee, S Maughan, T Falk, S J Staffurth, J Ray, R Bashir, N Geh, J I Cunningham, D Roy, R Bridgewater, J Griffiths, G Nixon, L S Blazeby, J M Crosby, T |
author_facet | Rees, J Hurt, C N Gollins, S Mukherjee, S Maughan, T Falk, S J Staffurth, J Ray, R Bashir, N Geh, J I Cunningham, D Roy, R Bridgewater, J Griffiths, G Nixon, L S Blazeby, J M Crosby, T |
author_sort | Rees, J |
collection | PubMed |
description | BACKGROUND: Limited data describe patient-reported outcomes (PROs) of localised oesophageal cancer treated with definitive chemoradiotherapy(CRT). The phase 2/3 SCOPE-1 trial assessed the effectiveness of CRT±cetuximab. The trial for the first time provided an opportunity to describe PROs from a multi-centre group of patients treated with CRT that are presented here. METHODS: Patients undergoing CRT±cetuximab within the SCOPE-1 trial (258 patients from 36 UK centres) completed generic-, disease- and treatment-specific health-related quality of life (HRQL) questionnaires (EORTC QLQ-C30, QLQ-OES18, Dermatology Life-Quality Index (DLQI)) at baseline and at 7, 13, 24, 52 and 104 weeks. Mean EORTC functional scale scores (>15 point change significant), DLQI scores (>4 point change significant) and proportions of patients (>15% significant) with ‘minimal' or ‘severe' symptoms are presented. RESULTS: Questionnaire response rates were good. At baseline, EORTC functional scores were high (>75%) and few symptoms were reported except for severe problems with fatigue, insomnia and eating-related symptoms (e.g., appetite loss, dysphagia, dry mouth) in both groups(>15%). Functional aspects of health deteriorated and symptoms increased with treatment and by week 13 global quality of life, physical, role and social function significantly deteriorated and more problems with fatigue, dyspnoea, appetite loss and trouble with taste were reported. Recovery occurred by 6 months (except severe fatigue and insomnia in >15% of patients) and maintained at follow-up with no differences between groups. CONCLUSIONS: CRT for localised oesophageal cancer has a significant detrimental impact on many aspects of HRQL; however, recovery is achieved by 6 months and maintained with the exception of persisting problems with severe fatigue and insomnia. The data suggest that the HRQL recovery after definitive CRT is quicker, and there is little lasting deficit compared with treatment including surgery. These data need to be compared with HRQL data from studies evaluating treatments including surgery for oesophageal cancer. |
format | Online Article Text |
id | pubmed-4647690 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-46476902016-08-11 Patient-reported outcomes during and after definitive chemoradiotherapy for oesophageal cancer Rees, J Hurt, C N Gollins, S Mukherjee, S Maughan, T Falk, S J Staffurth, J Ray, R Bashir, N Geh, J I Cunningham, D Roy, R Bridgewater, J Griffiths, G Nixon, L S Blazeby, J M Crosby, T Br J Cancer Clinical Study BACKGROUND: Limited data describe patient-reported outcomes (PROs) of localised oesophageal cancer treated with definitive chemoradiotherapy(CRT). The phase 2/3 SCOPE-1 trial assessed the effectiveness of CRT±cetuximab. The trial for the first time provided an opportunity to describe PROs from a multi-centre group of patients treated with CRT that are presented here. METHODS: Patients undergoing CRT±cetuximab within the SCOPE-1 trial (258 patients from 36 UK centres) completed generic-, disease- and treatment-specific health-related quality of life (HRQL) questionnaires (EORTC QLQ-C30, QLQ-OES18, Dermatology Life-Quality Index (DLQI)) at baseline and at 7, 13, 24, 52 and 104 weeks. Mean EORTC functional scale scores (>15 point change significant), DLQI scores (>4 point change significant) and proportions of patients (>15% significant) with ‘minimal' or ‘severe' symptoms are presented. RESULTS: Questionnaire response rates were good. At baseline, EORTC functional scores were high (>75%) and few symptoms were reported except for severe problems with fatigue, insomnia and eating-related symptoms (e.g., appetite loss, dysphagia, dry mouth) in both groups(>15%). Functional aspects of health deteriorated and symptoms increased with treatment and by week 13 global quality of life, physical, role and social function significantly deteriorated and more problems with fatigue, dyspnoea, appetite loss and trouble with taste were reported. Recovery occurred by 6 months (except severe fatigue and insomnia in >15% of patients) and maintained at follow-up with no differences between groups. CONCLUSIONS: CRT for localised oesophageal cancer has a significant detrimental impact on many aspects of HRQL; however, recovery is achieved by 6 months and maintained with the exception of persisting problems with severe fatigue and insomnia. The data suggest that the HRQL recovery after definitive CRT is quicker, and there is little lasting deficit compared with treatment including surgery. These data need to be compared with HRQL data from studies evaluating treatments including surgery for oesophageal cancer. Nature Publishing Group 2015-08-11 2015-07-23 /pmc/articles/PMC4647690/ /pubmed/26203761 http://dx.doi.org/10.1038/bjc.2015.258 Text en Copyright © 2015 Cancer Research UK http://creativecommons.org/licenses/by-nc-sa/4.0/ From twelve months after its original publication, this work is licensed under the Creative Commons Attribution-NonCommercial-Share Alike 4.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/ |
spellingShingle | Clinical Study Rees, J Hurt, C N Gollins, S Mukherjee, S Maughan, T Falk, S J Staffurth, J Ray, R Bashir, N Geh, J I Cunningham, D Roy, R Bridgewater, J Griffiths, G Nixon, L S Blazeby, J M Crosby, T Patient-reported outcomes during and after definitive chemoradiotherapy for oesophageal cancer |
title | Patient-reported outcomes during and after definitive chemoradiotherapy for oesophageal cancer |
title_full | Patient-reported outcomes during and after definitive chemoradiotherapy for oesophageal cancer |
title_fullStr | Patient-reported outcomes during and after definitive chemoradiotherapy for oesophageal cancer |
title_full_unstemmed | Patient-reported outcomes during and after definitive chemoradiotherapy for oesophageal cancer |
title_short | Patient-reported outcomes during and after definitive chemoradiotherapy for oesophageal cancer |
title_sort | patient-reported outcomes during and after definitive chemoradiotherapy for oesophageal cancer |
topic | Clinical Study |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4647690/ https://www.ncbi.nlm.nih.gov/pubmed/26203761 http://dx.doi.org/10.1038/bjc.2015.258 |
work_keys_str_mv | AT reesj patientreportedoutcomesduringandafterdefinitivechemoradiotherapyforoesophagealcancer AT hurtcn patientreportedoutcomesduringandafterdefinitivechemoradiotherapyforoesophagealcancer AT gollinss patientreportedoutcomesduringandafterdefinitivechemoradiotherapyforoesophagealcancer AT mukherjees patientreportedoutcomesduringandafterdefinitivechemoradiotherapyforoesophagealcancer AT maughant patientreportedoutcomesduringandafterdefinitivechemoradiotherapyforoesophagealcancer AT falksj patientreportedoutcomesduringandafterdefinitivechemoradiotherapyforoesophagealcancer AT staffurthj patientreportedoutcomesduringandafterdefinitivechemoradiotherapyforoesophagealcancer AT rayr patientreportedoutcomesduringandafterdefinitivechemoradiotherapyforoesophagealcancer AT bashirn patientreportedoutcomesduringandafterdefinitivechemoradiotherapyforoesophagealcancer AT gehji patientreportedoutcomesduringandafterdefinitivechemoradiotherapyforoesophagealcancer AT cunninghamd patientreportedoutcomesduringandafterdefinitivechemoradiotherapyforoesophagealcancer AT royr patientreportedoutcomesduringandafterdefinitivechemoradiotherapyforoesophagealcancer AT bridgewaterj patientreportedoutcomesduringandafterdefinitivechemoradiotherapyforoesophagealcancer AT griffithsg patientreportedoutcomesduringandafterdefinitivechemoradiotherapyforoesophagealcancer AT nixonls patientreportedoutcomesduringandafterdefinitivechemoradiotherapyforoesophagealcancer AT blazebyjm patientreportedoutcomesduringandafterdefinitivechemoradiotherapyforoesophagealcancer AT crosbyt patientreportedoutcomesduringandafterdefinitivechemoradiotherapyforoesophagealcancer |