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Zinc finger nuclease-based double-strand breaks attenuate malaria parasites and reveal rare microhomology-mediated end joining

BACKGROUND: Genome editing of malaria parasites is key to the generation of live attenuated parasites used in experimental vaccination approaches. DNA repair in Plasmodium generally occurs only through homologous recombination. This has been used to generate transgenic parasites that lack one to thr...

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Detalles Bibliográficos
Autores principales:	Singer, Mirko, Marshall, Jennifer, Heiss, Kirsten, Mair, Gunnar R., Grimm, Dirk, Mueller, Ann-Kristin, Frischknecht, Friedrich
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4647826/ https://www.ncbi.nlm.nih.gov/pubmed/26573820 http://dx.doi.org/10.1186/s13059-015-0811-1

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