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Structural insights into the reaction mechanism of S-adenosyl-L-homocysteine hydrolase

S-adenosyl-L-homocysteine hydrolase (SAH hydrolase or SAHH) is a highly conserved enzyme that catalyses the reversible hydrolysis of SAH to L-homocysteine (HCY) and adenosine (ADO). High-resolution crystal structures have been reported for bacterial and plant SAHHs, but not mammalian SAHHs. Here, we...

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Detalles Bibliográficos
Autores principales:	Kusakabe, Yoshio, Ishihara, Masaaki, Umeda, Tomonobu, Kuroda, Daisuke, Nakanishi, Masayuki, Kitade, Yukio, Gouda, Hiroaki, Nakamura, Kazuo T., Tanaka, Nobutada
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4647836/ https://www.ncbi.nlm.nih.gov/pubmed/26573329 http://dx.doi.org/10.1038/srep16641

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