PTEN loss in circulating tumour cells correlates with PTEN loss in fresh tumour tissue from castration-resistant prostate cancer patients

BACKGROUND: PTEN gene loss occurs frequently in castration-resistant prostate cancer (CRPC) and may drive progression through activation of the PI3K/AKT pathway. Here, we developed a novel CTC-based assay to determine PTEN status and examined the correlation between PTEN status in CTCs and matched t...

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Detalles Bibliográficos
Autores principales: Punnoose, Elizabeth A, Ferraldeschi, Roberta, Szafer-Glusman, Edith, Tucker, Eric K, Mohan, Sankar, Flohr, Penelope, Riisnaes, Ruth, Miranda, Susana, Figueiredo, Ines, Rodrigues, Daniel Nava, Omlin, Aurelius, Pezaro, Carmel, Zhu, Jin, Amler, Lukas, Patel, Premal, Yan, Yibing, Bales, Natalee, Werner, Shannon L, Louw, Jessica, Pandita, Ajay, Marrinucci, Dena, Attard, Gerhardt, de Bono, Johann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Molecular Diagnostics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4647881/
https://www.ncbi.nlm.nih.gov/pubmed/26379078
http://dx.doi.org/10.1038/bjc.2015.332

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