hORFeome v3.1: A resource of human open reading frames representing over 10,000 human genes

Complete sets of cloned protein-encoding open reading frames (ORFs), or ORFeomes, are essential tools for large-scale proteomics and systems biology studies. Here we describe human ORFeome version 3.1 (hORFeome v3.1), currently the largest publicly available resource of full-length human ORFs (avail...

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Detalles Bibliográficos
Autores principales: Lamesch, Philippe, Li, Ning, Milstein, Stuart, Fan, Changyu, Hao, Tong, Szabo, Gabor, Hu, Zhenjun, Venkatesan, Kavitha, Bethel, Graeme, Martin, Paul, Rogers, Jane, Lawlor, Stephanie, McLaren, Stuart, Dricot, Amélie, Borick, Heather, Cusick, Michael E., Vandenhaute, Jean, Dunham, Ian, Hill, David E., Vidal, Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Academic Press 2007
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4647941/
https://www.ncbi.nlm.nih.gov/pubmed/17207965
http://dx.doi.org/10.1016/j.ygeno.2006.11.012
Descripción
Sumario:Complete sets of cloned protein-encoding open reading frames (ORFs), or ORFeomes, are essential tools for large-scale proteomics and systems biology studies. Here we describe human ORFeome version 3.1 (hORFeome v3.1), currently the largest publicly available resource of full-length human ORFs (available at www.openbiosystems.com). Generated by Gateway recombinational cloning, this collection contains 12,212 ORFs, representing 10,214 human genes, and corresponds to a 51% expansion of the original hORFeome v1.1. An online human ORFeome database, hORFDB, was built and serves as the central repository for all cloned human ORFs (http://horfdb.dfci.harvard.edu). This expansion of the original ORFeome resource greatly increases the potential experimental search space for large-scale proteomics studies, which will lead to the generation of more comprehensive datasets.

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