Activity-Directed Synthesis with Intermolecular Reactions: Development of a Fragment into a Range of Androgen Receptor Agonists

Activity-directed synthesis (ADS), a novel discovery approach in which bioactive molecules emerge in parallel with associated syntheses, was exploited to develop a weakly binding fragment into novel androgen receptor agonists. Harnessing promiscuous intermolecular reactions of carbenoid compounds en...

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Detalles Bibliográficos
Autores principales: Karageorgis, George, Dow, Mark, Aimon, Anthony, Warriner, Stuart, Nelson, Adam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: WILEY-VCH Verlag 2015
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4648041/
https://www.ncbi.nlm.nih.gov/pubmed/26358926
http://dx.doi.org/10.1002/anie.201506944

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4648041/
https://www.ncbi.nlm.nih.gov/pubmed/26358926
http://dx.doi.org/10.1002/anie.201506944

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