NHC-Catalyzed Asymmetric Synthesis of Functionalized Succinimides from Enals and α-Ketoamides

The efficient asymmetric synthesis of highly substituted succinimides from α,β-unsaturated aldehydes and α-ketoamides via NHC-catalyzed [3+2] cycloaddition has been developed. The new scalable protocol significantly expands the utility of NHC catalysis for the synthesis of heterocycles and provides...

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Detalles Bibliográficos
Autores principales: Wang, Lei, Ni, Qijian, Blümel, Marcus, Shu, Tao, Raabe, Gerhard, Enders, Dieter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: WILEY-VCH Verlag 2015
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4648042/
https://www.ncbi.nlm.nih.gov/pubmed/25877658
http://dx.doi.org/10.1002/chem.201500661
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author Wang, Lei
Ni, Qijian
Blümel, Marcus
Shu, Tao
Raabe, Gerhard
Enders, Dieter
author_facet Wang, Lei
Ni, Qijian
Blümel, Marcus
Shu, Tao
Raabe, Gerhard
Enders, Dieter
author_sort Wang, Lei
collection PubMed
description The efficient asymmetric synthesis of highly substituted succinimides from α,β-unsaturated aldehydes and α-ketoamides via NHC-catalyzed [3+2] cycloaddition has been developed. The new scalable protocol significantly expands the utility of NHC catalysis for the synthesis of heterocycles and provides easy access to assemble a wide range of succinimides from simple starting materials.
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spelling pubmed-46480422015-11-24 NHC-Catalyzed Asymmetric Synthesis of Functionalized Succinimides from Enals and α-Ketoamides Wang, Lei Ni, Qijian Blümel, Marcus Shu, Tao Raabe, Gerhard Enders, Dieter Chemistry Communications The efficient asymmetric synthesis of highly substituted succinimides from α,β-unsaturated aldehydes and α-ketoamides via NHC-catalyzed [3+2] cycloaddition has been developed. The new scalable protocol significantly expands the utility of NHC catalysis for the synthesis of heterocycles and provides easy access to assemble a wide range of succinimides from simple starting materials. WILEY-VCH Verlag 2015-05-26 2015-04-15 /pmc/articles/PMC4648042/ /pubmed/25877658 http://dx.doi.org/10.1002/chem.201500661 Text en © 2015 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. https://creativecommons.org/licenses/by-nc/4.0/ © 2015 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Communications
Wang, Lei
Ni, Qijian
Blümel, Marcus
Shu, Tao
Raabe, Gerhard
Enders, Dieter
NHC-Catalyzed Asymmetric Synthesis of Functionalized Succinimides from Enals and α-Ketoamides
title NHC-Catalyzed Asymmetric Synthesis of Functionalized Succinimides from Enals and α-Ketoamides
title_full NHC-Catalyzed Asymmetric Synthesis of Functionalized Succinimides from Enals and α-Ketoamides
title_fullStr NHC-Catalyzed Asymmetric Synthesis of Functionalized Succinimides from Enals and α-Ketoamides
title_full_unstemmed NHC-Catalyzed Asymmetric Synthesis of Functionalized Succinimides from Enals and α-Ketoamides
title_short NHC-Catalyzed Asymmetric Synthesis of Functionalized Succinimides from Enals and α-Ketoamides
title_sort nhc-catalyzed asymmetric synthesis of functionalized succinimides from enals and α-ketoamides
topic Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4648042/
https://www.ncbi.nlm.nih.gov/pubmed/25877658
http://dx.doi.org/10.1002/chem.201500661
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