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Redox Modulation of PTEN Phosphatase Activity by Hydrogen Peroxide and Bisperoxidovanadium Complexes
PTEN is a dual-specificity protein tyrosine phosphatase. As one of the central tumor suppressors, a thorough regulation of its activity is essential for proper cellular homeostasis. The precise implications of PTEN inhibition by reactive oxygen species (e.g. H(2)O(2)) and the subsequent structural c...
Autores principales: | Lee, Chang-Uk, Hahne, Gernot, Hanske, Jonas, Bange, Tanja, Bier, David, Rademacher, Christoph, Hennig, Sven, Grossmann, Tom N |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
WILEY-VCH Verlag
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4648047/ https://www.ncbi.nlm.nih.gov/pubmed/26418532 http://dx.doi.org/10.1002/anie.201506338 |
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