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A Universal Base in a Specific Role: Tuning up a Thrombin Aptamer with 5-Nitroindole

In this study we describe new modified analogs of the thrombin binding aptamer (TBA) containing 5-nitroindole residues. It has been shown that all modified TBAs form an anti-parallel G-quadruplex structure and retain the ability to inhibit thrombin. The most advanced TBA variant (TBA-N8) has a subst...

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Detalles Bibliográficos
Autores principales:	Tsvetkov, Vladimir B., Varizhuk, Anna M., Pozmogova, Galina E., Smirnov, Igor P., Kolganova, Natalia A., Timofeev, Edward N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4648099/ http://dx.doi.org/10.1038/srep16337

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