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Identification and in vitro pharmacological characterization of a novel and selective α7 nicotinic acetylcholine receptor agonist, Br-IQ17B

AIM: Alpha7-nicotinic acetylcholine receptor (α7 nAChR) is a ligand-gated Ca(2+)-permeable ion channel implicated in cognition and neuropsychiatric disorders. Activation of α7 nAChR improves learning, memory, and sensory gating in animal models. To identify novel α7 nAChR agonists, we synthesized a...

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Detalles Bibliográficos
Autores principales:	Tang, Jing-shu, Xie, Bing-xue, Bian, Xi-ling, Xue, Yu, Wei, Ning-ning, Zhou, Jing-heng, Hao, Yu-chen, Li, Gang, Zhang, Liang-ren, Wang, Ke-wei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4648113/ https://www.ncbi.nlm.nih.gov/pubmed/25948478 http://dx.doi.org/10.1038/aps.2015.9

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