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Large Variation in Brain Exposure of Reference CNS Drugs: a PET Study in Nonhuman Primates

BACKGROUND: Positron emission tomography microdosing of radiolabeled drugs allows for noninvasive studies of organ exposure in vivo. The aim of the present study was to examine and compare the brain exposure of 12 commercially available CNS drugs and one non-CNS drug. METHODS: The drugs were radiola...

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Detalles Bibliográficos
Autores principales:	Schou, Magnus, Varnäs, Katarina, Lundquist, Stefan, Nakao, Ryuji, Amini, Nahid, Takano, Akihiro, Finnema, Sjoerd J., Halldin, Christer, Farde, Lars
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4648157/ https://www.ncbi.nlm.nih.gov/pubmed/25813017 http://dx.doi.org/10.1093/ijnp/pyv036

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