Inhibition of NAADP signalling on reperfusion protects the heart by preventing lethal calcium oscillations via two-pore channel 1 and opening of the mitochondrial permeability transition pore

AIMS: In the heart, a period of ischaemia followed by reperfusion evokes powerful cytosolic Ca(2+) oscillations that can cause lethal cell injury. These signals represent attractive cardioprotective targets, but the underlying mechanisms of genesis are ill-defined. Here, we investigated the role of...

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Detalles Bibliográficos
Autores principales: Davidson, Sean M., Foote, Kirsty, Kunuthur, Suma, Gosain, Raj, Tan, Noah, Tyser, Richard, Zhao, Yong Juan, Graeff, Richard, Ganesan, A., Duchen, Michael R., Patel, Sandip, Yellon, Derek M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
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Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4648198/
https://www.ncbi.nlm.nih.gov/pubmed/26395965
http://dx.doi.org/10.1093/cvr/cvv226

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