Cyclic AMP Mimics the Anti-ageing Effects of Calorie Restriction by Up-Regulating Sirtuin

Cyclic adenosine monophosphate (cAMP) plays an important role in many biological processes as a second messenger, and cAMP treatment has been reported to extend the lifespan of wild-type Drosophila melanogaster. Our study showed that exogenous cAMP improved ageing-related phenotypes by increasing th...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Zhuoran, Zhang, Lu, Liang, Yaru, Zhang, Chi, Xu, Zhiyu, Zhang, Lang, Fuji, Ryosuke, Mu, Wei, Li, Liyuan, Jiang, Junjun, Ju, Yong, Wang, Zhao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4648391/
https://www.ncbi.nlm.nih.gov/pubmed/26153625
http://dx.doi.org/10.1038/srep12012
_version_ 1782401223120388096
author Wang, Zhuoran
Zhang, Lu
Liang, Yaru
Zhang, Chi
Xu, Zhiyu
Zhang, Lang
Fuji, Ryosuke
Mu, Wei
Li, Liyuan
Jiang, Junjun
Ju, Yong
Wang, Zhao
author_facet Wang, Zhuoran
Zhang, Lu
Liang, Yaru
Zhang, Chi
Xu, Zhiyu
Zhang, Lang
Fuji, Ryosuke
Mu, Wei
Li, Liyuan
Jiang, Junjun
Ju, Yong
Wang, Zhao
author_sort Wang, Zhuoran
collection PubMed
description Cyclic adenosine monophosphate (cAMP) plays an important role in many biological processes as a second messenger, and cAMP treatment has been reported to extend the lifespan of wild-type Drosophila melanogaster. Our study showed that exogenous cAMP improved ageing-related phenotypes by increasing the protein level of Sirtuins, which prevented metabolic disorders to mimic the effect of calorie restriction. Experiments in vitro showed that cAMP directly bound to SIRT1 and SIRT3 and consequently increased their activity. These findings suggest that cAMP slows the ageing process and is a good candidate to mimic calorie restriction. Our research provides a promising therapeutic strategy to target metabolic disorder-induced ageing-related diseases.
format Online
Article
Text
id pubmed-4648391
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-46483912015-11-23 Cyclic AMP Mimics the Anti-ageing Effects of Calorie Restriction by Up-Regulating Sirtuin Wang, Zhuoran Zhang, Lu Liang, Yaru Zhang, Chi Xu, Zhiyu Zhang, Lang Fuji, Ryosuke Mu, Wei Li, Liyuan Jiang, Junjun Ju, Yong Wang, Zhao Sci Rep Article Cyclic adenosine monophosphate (cAMP) plays an important role in many biological processes as a second messenger, and cAMP treatment has been reported to extend the lifespan of wild-type Drosophila melanogaster. Our study showed that exogenous cAMP improved ageing-related phenotypes by increasing the protein level of Sirtuins, which prevented metabolic disorders to mimic the effect of calorie restriction. Experiments in vitro showed that cAMP directly bound to SIRT1 and SIRT3 and consequently increased their activity. These findings suggest that cAMP slows the ageing process and is a good candidate to mimic calorie restriction. Our research provides a promising therapeutic strategy to target metabolic disorder-induced ageing-related diseases. Nature Publishing Group 2015-07-08 /pmc/articles/PMC4648391/ /pubmed/26153625 http://dx.doi.org/10.1038/srep12012 Text en Copyright © 2015, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Wang, Zhuoran
Zhang, Lu
Liang, Yaru
Zhang, Chi
Xu, Zhiyu
Zhang, Lang
Fuji, Ryosuke
Mu, Wei
Li, Liyuan
Jiang, Junjun
Ju, Yong
Wang, Zhao
Cyclic AMP Mimics the Anti-ageing Effects of Calorie Restriction by Up-Regulating Sirtuin
title Cyclic AMP Mimics the Anti-ageing Effects of Calorie Restriction by Up-Regulating Sirtuin
title_full Cyclic AMP Mimics the Anti-ageing Effects of Calorie Restriction by Up-Regulating Sirtuin
title_fullStr Cyclic AMP Mimics the Anti-ageing Effects of Calorie Restriction by Up-Regulating Sirtuin
title_full_unstemmed Cyclic AMP Mimics the Anti-ageing Effects of Calorie Restriction by Up-Regulating Sirtuin
title_short Cyclic AMP Mimics the Anti-ageing Effects of Calorie Restriction by Up-Regulating Sirtuin
title_sort cyclic amp mimics the anti-ageing effects of calorie restriction by up-regulating sirtuin
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4648391/
https://www.ncbi.nlm.nih.gov/pubmed/26153625
http://dx.doi.org/10.1038/srep12012
work_keys_str_mv AT wangzhuoran cyclicampmimicstheantiageingeffectsofcalorierestrictionbyupregulatingsirtuin
AT zhanglu cyclicampmimicstheantiageingeffectsofcalorierestrictionbyupregulatingsirtuin
AT liangyaru cyclicampmimicstheantiageingeffectsofcalorierestrictionbyupregulatingsirtuin
AT zhangchi cyclicampmimicstheantiageingeffectsofcalorierestrictionbyupregulatingsirtuin
AT xuzhiyu cyclicampmimicstheantiageingeffectsofcalorierestrictionbyupregulatingsirtuin
AT zhanglang cyclicampmimicstheantiageingeffectsofcalorierestrictionbyupregulatingsirtuin
AT fujiryosuke cyclicampmimicstheantiageingeffectsofcalorierestrictionbyupregulatingsirtuin
AT muwei cyclicampmimicstheantiageingeffectsofcalorierestrictionbyupregulatingsirtuin
AT liliyuan cyclicampmimicstheantiageingeffectsofcalorierestrictionbyupregulatingsirtuin
AT jiangjunjun cyclicampmimicstheantiageingeffectsofcalorierestrictionbyupregulatingsirtuin
AT juyong cyclicampmimicstheantiageingeffectsofcalorierestrictionbyupregulatingsirtuin
AT wangzhao cyclicampmimicstheantiageingeffectsofcalorierestrictionbyupregulatingsirtuin

Ejemplares similares