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Exploring Host-Microbiome Interactions using an in Silico Model of Biomimetic Robots and Engineered Living Cells

The microbiome’s underlying dynamics play an important role in regulating the behavior and health of its host. In order to explore the details of these interactions, we created an in silico model of a living microbiome, engineered with synthetic biology, that interfaces with a biomimetic, robotic ho...

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Detalles Bibliográficos
Autores principales: Heyde, Keith C., Ruder, Warren C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4648426/
https://www.ncbi.nlm.nih.gov/pubmed/26178309
http://dx.doi.org/10.1038/srep11988
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author Heyde, Keith C.
Ruder, Warren C.
author_facet Heyde, Keith C.
Ruder, Warren C.
author_sort Heyde, Keith C.
collection PubMed
description The microbiome’s underlying dynamics play an important role in regulating the behavior and health of its host. In order to explore the details of these interactions, we created an in silico model of a living microbiome, engineered with synthetic biology, that interfaces with a biomimetic, robotic host. By analytically modeling and computationally simulating engineered gene networks in these commensal communities, we reproduced complex behaviors in the host. We observed that robot movements depended upon programmed biochemical network dynamics within the microbiome. These results illustrate the model’s potential utility as a tool for exploring inter-kingdom ecological relationships. These systems could impact fields ranging from synthetic biology and ecology to biophysics and medicine.
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spelling pubmed-46484262015-11-23 Exploring Host-Microbiome Interactions using an in Silico Model of Biomimetic Robots and Engineered Living Cells Heyde, Keith C. Ruder, Warren C. Sci Rep Article The microbiome’s underlying dynamics play an important role in regulating the behavior and health of its host. In order to explore the details of these interactions, we created an in silico model of a living microbiome, engineered with synthetic biology, that interfaces with a biomimetic, robotic host. By analytically modeling and computationally simulating engineered gene networks in these commensal communities, we reproduced complex behaviors in the host. We observed that robot movements depended upon programmed biochemical network dynamics within the microbiome. These results illustrate the model’s potential utility as a tool for exploring inter-kingdom ecological relationships. These systems could impact fields ranging from synthetic biology and ecology to biophysics and medicine. Nature Publishing Group 2015-07-16 /pmc/articles/PMC4648426/ /pubmed/26178309 http://dx.doi.org/10.1038/srep11988 Text en Copyright © 2015, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Heyde, Keith C.
Ruder, Warren C.
Exploring Host-Microbiome Interactions using an in Silico Model of Biomimetic Robots and Engineered Living Cells
title Exploring Host-Microbiome Interactions using an in Silico Model of Biomimetic Robots and Engineered Living Cells
title_full Exploring Host-Microbiome Interactions using an in Silico Model of Biomimetic Robots and Engineered Living Cells
title_fullStr Exploring Host-Microbiome Interactions using an in Silico Model of Biomimetic Robots and Engineered Living Cells
title_full_unstemmed Exploring Host-Microbiome Interactions using an in Silico Model of Biomimetic Robots and Engineered Living Cells
title_short Exploring Host-Microbiome Interactions using an in Silico Model of Biomimetic Robots and Engineered Living Cells
title_sort exploring host-microbiome interactions using an in silico model of biomimetic robots and engineered living cells
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4648426/
https://www.ncbi.nlm.nih.gov/pubmed/26178309
http://dx.doi.org/10.1038/srep11988
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