MitoRCA-seq reveals unbalanced cytocine to thymine transition in Polg mutant mice

Mutations in mitochondrial DNA (mtDNA) can lead to a wide range of human diseases. We have developed a deep sequencing strategy, mitoRCA-seq, to detect low-frequency mtDNA point mutations starting with as little as 1 ng of total DNA. It employs rolling circle amplification, which enriches the full-l...

Descripción completa

Detalles Bibliográficos
Autores principales: Ni, Ting, Wei, Gang, Shen, Ting, Han, Miao, Lian, Yaru, Fu, Haihui, Luo, Yan, Yang, Yanqin, Liu, Jie, Wakabayashi, Yoshi, Li, Zheng, Finkel, Toren, Xu, Hong, Zhu, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4648470/
https://www.ncbi.nlm.nih.gov/pubmed/26212336
http://dx.doi.org/10.1038/srep12049

Ejemplares similares

Ejemplares similares