Defining the contribution of MC1R physiological ligands to ATR phosphorylation at Ser435, a predictor of DNA repair in melanocytes

The melanocortin 1 receptor (MC1R), a G(S)-coupled receptor that signals through cAMP and PKA, regulates pigmentation, adaptive tanning, and melanoma resistance. MC1R-cAMP signaling promotes PKA-mediated phosphorylation of ataxia telangiectasia and rad3-related (ATR) at Ser435 (ATR-pS435), a modific...

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Detalles Bibliográficos
Autores principales: Jarrett, Stuart G., Wolf Horrell, Erin M., Boulanger, Mary C., D’Orazio, John A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4648643/
https://www.ncbi.nlm.nih.gov/pubmed/26168232
http://dx.doi.org/10.1038/jid.2015.280

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4648643/
https://www.ncbi.nlm.nih.gov/pubmed/26168232
http://dx.doi.org/10.1038/jid.2015.280

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