BRAF inhibition generates a host/tumor niche that mediates therapeutic escape

The current study defines a fibroblast-derived niche that facilitates the therapeutic escape of melanoma cells from BRAF inhibition. Vemurafenib treatment led to the release of TGF-β from the melanoma cells that increased the differentiation state of the fibroblasts; an affect associated with fibron...

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Detalles Bibliográficos
Autores principales: Fedorenko, Inna V., Wargo, Jennifer A., Flaherty, Keith T., Messina, Jane L., Smalley, Keiran S.M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4648653/
https://www.ncbi.nlm.nih.gov/pubmed/26302068
http://dx.doi.org/10.1038/jid.2015.329

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4648653/
https://www.ncbi.nlm.nih.gov/pubmed/26302068
http://dx.doi.org/10.1038/jid.2015.329

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