Beyond red hair and sunburns: Uncovering the molecular mechanisms of MC1R signaling and repair of UV-induced DNA damage

Scientists at the University of Kentucky are unravelling the details of DNA damage repair in the melanocyte, with an eye towards finding druggable targets for melanoma prevention. Jarret et al. report in this issue three new assays that can yield mechanistic information about nucleotide excision rep...

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Detalles Bibliográficos
Autores principales: Cassidy, Pamela B., Abdel-Malek, Zalfa A., Leachman, Sancy A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4648680/
https://www.ncbi.nlm.nih.gov/pubmed/26569585
http://dx.doi.org/10.1038/jid.2015.349
Descripción
Sumario:Scientists at the University of Kentucky are unravelling the details of DNA damage repair in the melanocyte, with an eye towards finding druggable targets for melanoma prevention. Jarret et al. report in this issue three new assays that can yield mechanistic information about nucleotide excision repair (NER) stimulated by cAMP-dependent signaling downstream of the melanocortin-1 receptor (MC1R).

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