Beyond red hair and sunburns: Uncovering the molecular mechanisms of MC1R signaling and repair of UV-induced DNA damage

Scientists at the University of Kentucky are unravelling the details of DNA damage repair in the melanocyte, with an eye towards finding druggable targets for melanoma prevention. Jarret et al. report in this issue three new assays that can yield mechanistic information about nucleotide excision rep...

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Detalles Bibliográficos
Autores principales: Cassidy, Pamela B., Abdel-Malek, Zalfa A., Leachman, Sancy A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4648680/
https://www.ncbi.nlm.nih.gov/pubmed/26569585
http://dx.doi.org/10.1038/jid.2015.349
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author Cassidy, Pamela B.
Abdel-Malek, Zalfa A.
Leachman, Sancy A.
author_facet Cassidy, Pamela B.
Abdel-Malek, Zalfa A.
Leachman, Sancy A.
author_sort Cassidy, Pamela B.
collection PubMed
description Scientists at the University of Kentucky are unravelling the details of DNA damage repair in the melanocyte, with an eye towards finding druggable targets for melanoma prevention. Jarret et al. report in this issue three new assays that can yield mechanistic information about nucleotide excision repair (NER) stimulated by cAMP-dependent signaling downstream of the melanocortin-1 receptor (MC1R).
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spelling pubmed-46486802016-06-01 Beyond red hair and sunburns: Uncovering the molecular mechanisms of MC1R signaling and repair of UV-induced DNA damage Cassidy, Pamela B. Abdel-Malek, Zalfa A. Leachman, Sancy A. J Invest Dermatol Article Scientists at the University of Kentucky are unravelling the details of DNA damage repair in the melanocyte, with an eye towards finding druggable targets for melanoma prevention. Jarret et al. report in this issue three new assays that can yield mechanistic information about nucleotide excision repair (NER) stimulated by cAMP-dependent signaling downstream of the melanocortin-1 receptor (MC1R). 2015-12 /pmc/articles/PMC4648680/ /pubmed/26569585 http://dx.doi.org/10.1038/jid.2015.349 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Cassidy, Pamela B.
Abdel-Malek, Zalfa A.
Leachman, Sancy A.
Beyond red hair and sunburns: Uncovering the molecular mechanisms of MC1R signaling and repair of UV-induced DNA damage
title Beyond red hair and sunburns: Uncovering the molecular mechanisms of MC1R signaling and repair of UV-induced DNA damage
title_full Beyond red hair and sunburns: Uncovering the molecular mechanisms of MC1R signaling and repair of UV-induced DNA damage
title_fullStr Beyond red hair and sunburns: Uncovering the molecular mechanisms of MC1R signaling and repair of UV-induced DNA damage
title_full_unstemmed Beyond red hair and sunburns: Uncovering the molecular mechanisms of MC1R signaling and repair of UV-induced DNA damage
title_short Beyond red hair and sunburns: Uncovering the molecular mechanisms of MC1R signaling and repair of UV-induced DNA damage
title_sort beyond red hair and sunburns: uncovering the molecular mechanisms of mc1r signaling and repair of uv-induced dna damage
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4648680/
https://www.ncbi.nlm.nih.gov/pubmed/26569585
http://dx.doi.org/10.1038/jid.2015.349
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