Cargando…

Evaluation of safety profile of thoracoscopic esophagectomy for T1bN0M0 cancer using data from JCOG0502: a prospective multicenter study

BACKGROUND: Thoracoscopic esophagectomy is rapidly and increasingly being used worldwide because it is a less invasive alternative to open esophagectomy. However, few prospective multicenter studies have evaluated its safety profile. This study aimed to evaluate the safety profile of thoracoscopic e...

Descripción completa

Detalles Bibliográficos
Autores principales: Nozaki, Isao, Kato, Ken, Igaki, Hiroyasu, Ito, Yoshinori, Daiko, Hiroyuki, Yano, Masahiko, Udagawa, Harushi, Mizusawa, Junki, Katayama, Hiroshi, Nakamura, Kenichi, Kitagawa, Yuko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4648951/
https://www.ncbi.nlm.nih.gov/pubmed/25676203
http://dx.doi.org/10.1007/s00464-015-4102-4
_version_ 1782401283613786112
author Nozaki, Isao
Kato, Ken
Igaki, Hiroyasu
Ito, Yoshinori
Daiko, Hiroyuki
Yano, Masahiko
Udagawa, Harushi
Mizusawa, Junki
Katayama, Hiroshi
Nakamura, Kenichi
Kitagawa, Yuko
author_facet Nozaki, Isao
Kato, Ken
Igaki, Hiroyasu
Ito, Yoshinori
Daiko, Hiroyuki
Yano, Masahiko
Udagawa, Harushi
Mizusawa, Junki
Katayama, Hiroshi
Nakamura, Kenichi
Kitagawa, Yuko
author_sort Nozaki, Isao
collection PubMed
description BACKGROUND: Thoracoscopic esophagectomy is rapidly and increasingly being used worldwide because it is a less invasive alternative to open esophagectomy. However, few prospective multicenter studies have evaluated its safety profile. This study aimed to evaluate the safety profile of thoracoscopic esophagectomy using perioperative data from the Japan Clinical Oncology Group Study (JCOG0502). METHODS: JCOG0502 is a four-arm prospective study comparing esophagectomy with chemoradiotherapy for esophageal cancer, with randomized and patient preference arms. Patients with clinical stage T1bN0M0 esophageal cancer were enrolled until patient accrual was completed. Open or thoracoscopic esophagectomy was selected at the surgeon’s discretion. Perioperative complications were defined as adverse events of ≥grade 2 as per Common Terminology Criteria for Adverse Events ver. 3.0. RESULTS: A total of 379 patients were enrolled between December 2006 and February 2013. Of the 210 patients who underwent surgery, 109 patients underwent open esophagectomy, and 101 patients underwent thoracoscopic esophagectomy. Although thoracoscopic esophagectomy decreased the incidence of postoperative atelectasis (open: 22.0 %, thoracoscopy: 10.9 %; P = 0.041), reoperation was more frequent in the thoracoscopy group (open: 1.8 %, thoracoscopy: 9.9 %; P = 0.016). The incidence of overall complications did not differ between the two groups (open: 44.0 %, thoracoscopy: 44.6 %; P = 1.00). There was one in-hospital death in each group (open: 0.9 %, thoracoscopy: 1.0 %; P = 1.00). CONCLUSIONS: Thoracoscopic esophagectomy is a safe procedure with morbidity and mortality comparable with those of open esophagectomy. However, it is associated with a higher frequency of reoperation.
format Online
Article
Text
id pubmed-4648951
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Springer US
record_format MEDLINE/PubMed
spelling pubmed-46489512015-11-24 Evaluation of safety profile of thoracoscopic esophagectomy for T1bN0M0 cancer using data from JCOG0502: a prospective multicenter study Nozaki, Isao Kato, Ken Igaki, Hiroyasu Ito, Yoshinori Daiko, Hiroyuki Yano, Masahiko Udagawa, Harushi Mizusawa, Junki Katayama, Hiroshi Nakamura, Kenichi Kitagawa, Yuko Surg Endosc Article BACKGROUND: Thoracoscopic esophagectomy is rapidly and increasingly being used worldwide because it is a less invasive alternative to open esophagectomy. However, few prospective multicenter studies have evaluated its safety profile. This study aimed to evaluate the safety profile of thoracoscopic esophagectomy using perioperative data from the Japan Clinical Oncology Group Study (JCOG0502). METHODS: JCOG0502 is a four-arm prospective study comparing esophagectomy with chemoradiotherapy for esophageal cancer, with randomized and patient preference arms. Patients with clinical stage T1bN0M0 esophageal cancer were enrolled until patient accrual was completed. Open or thoracoscopic esophagectomy was selected at the surgeon’s discretion. Perioperative complications were defined as adverse events of ≥grade 2 as per Common Terminology Criteria for Adverse Events ver. 3.0. RESULTS: A total of 379 patients were enrolled between December 2006 and February 2013. Of the 210 patients who underwent surgery, 109 patients underwent open esophagectomy, and 101 patients underwent thoracoscopic esophagectomy. Although thoracoscopic esophagectomy decreased the incidence of postoperative atelectasis (open: 22.0 %, thoracoscopy: 10.9 %; P = 0.041), reoperation was more frequent in the thoracoscopy group (open: 1.8 %, thoracoscopy: 9.9 %; P = 0.016). The incidence of overall complications did not differ between the two groups (open: 44.0 %, thoracoscopy: 44.6 %; P = 1.00). There was one in-hospital death in each group (open: 0.9 %, thoracoscopy: 1.0 %; P = 1.00). CONCLUSIONS: Thoracoscopic esophagectomy is a safe procedure with morbidity and mortality comparable with those of open esophagectomy. However, it is associated with a higher frequency of reoperation. Springer US 2015-02-13 2015 /pmc/articles/PMC4648951/ /pubmed/25676203 http://dx.doi.org/10.1007/s00464-015-4102-4 Text en © The Author(s) 2015 https://creativecommons.org/licenses/by/4.0/ Open AccessThis article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Article
Nozaki, Isao
Kato, Ken
Igaki, Hiroyasu
Ito, Yoshinori
Daiko, Hiroyuki
Yano, Masahiko
Udagawa, Harushi
Mizusawa, Junki
Katayama, Hiroshi
Nakamura, Kenichi
Kitagawa, Yuko
Evaluation of safety profile of thoracoscopic esophagectomy for T1bN0M0 cancer using data from JCOG0502: a prospective multicenter study
title Evaluation of safety profile of thoracoscopic esophagectomy for T1bN0M0 cancer using data from JCOG0502: a prospective multicenter study
title_full Evaluation of safety profile of thoracoscopic esophagectomy for T1bN0M0 cancer using data from JCOG0502: a prospective multicenter study
title_fullStr Evaluation of safety profile of thoracoscopic esophagectomy for T1bN0M0 cancer using data from JCOG0502: a prospective multicenter study
title_full_unstemmed Evaluation of safety profile of thoracoscopic esophagectomy for T1bN0M0 cancer using data from JCOG0502: a prospective multicenter study
title_short Evaluation of safety profile of thoracoscopic esophagectomy for T1bN0M0 cancer using data from JCOG0502: a prospective multicenter study
title_sort evaluation of safety profile of thoracoscopic esophagectomy for t1bn0m0 cancer using data from jcog0502: a prospective multicenter study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4648951/
https://www.ncbi.nlm.nih.gov/pubmed/25676203
http://dx.doi.org/10.1007/s00464-015-4102-4
work_keys_str_mv AT nozakiisao evaluationofsafetyprofileofthoracoscopicesophagectomyfort1bn0m0cancerusingdatafromjcog0502aprospectivemulticenterstudy
AT katoken evaluationofsafetyprofileofthoracoscopicesophagectomyfort1bn0m0cancerusingdatafromjcog0502aprospectivemulticenterstudy
AT igakihiroyasu evaluationofsafetyprofileofthoracoscopicesophagectomyfort1bn0m0cancerusingdatafromjcog0502aprospectivemulticenterstudy
AT itoyoshinori evaluationofsafetyprofileofthoracoscopicesophagectomyfort1bn0m0cancerusingdatafromjcog0502aprospectivemulticenterstudy
AT daikohiroyuki evaluationofsafetyprofileofthoracoscopicesophagectomyfort1bn0m0cancerusingdatafromjcog0502aprospectivemulticenterstudy
AT yanomasahiko evaluationofsafetyprofileofthoracoscopicesophagectomyfort1bn0m0cancerusingdatafromjcog0502aprospectivemulticenterstudy
AT udagawaharushi evaluationofsafetyprofileofthoracoscopicesophagectomyfort1bn0m0cancerusingdatafromjcog0502aprospectivemulticenterstudy
AT mizusawajunki evaluationofsafetyprofileofthoracoscopicesophagectomyfort1bn0m0cancerusingdatafromjcog0502aprospectivemulticenterstudy
AT katayamahiroshi evaluationofsafetyprofileofthoracoscopicesophagectomyfort1bn0m0cancerusingdatafromjcog0502aprospectivemulticenterstudy
AT nakamurakenichi evaluationofsafetyprofileofthoracoscopicesophagectomyfort1bn0m0cancerusingdatafromjcog0502aprospectivemulticenterstudy
AT kitagawayuko evaluationofsafetyprofileofthoracoscopicesophagectomyfort1bn0m0cancerusingdatafromjcog0502aprospectivemulticenterstudy