Two distinct β-sheet structures in Italian-mutant amyloid-beta fibrils: a potential link to different clinical phenotypes

Most Alzheimer’s disease (AD) cases are late-onset and characterized by the aggregation and deposition of the amyloid-beta (Aβ) peptide in extracellular plaques in the brain. However, a few rare and hereditary Aβ mutations, such as the Italian Glu(22)-to-Lys (E22K) mutation, guarantee the developmen...

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Detalles Bibliográficos
Autores principales: Hubin, Ellen, Deroo, Stéphanie, Schierle, Gabriele Kaminksi, Kaminski, Clemens, Serpell, Louise, Subramaniam, Vinod, van Nuland, Nico, Broersen, Kerensa, Raussens, Vincent, Sarroukh, Rabia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4648968/
https://www.ncbi.nlm.nih.gov/pubmed/26190022
http://dx.doi.org/10.1007/s00018-015-1983-2

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