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Mechanisms of Disease: Host-Pathogen Interactions between Burkholderia Species and Lung Epithelial Cells

Members of the Burkholderia species can cause a range of severe, often fatal, respiratory diseases. A variety of in vitro models of infection have been developed in an attempt to elucidate the mechanism by which Burkholderia spp. gain entry to and interact with the body. The majority of studies have...

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Detalles Bibliográficos
Autores principales: David, Jonathan, Bell, Rachel E., Clark, Graeme C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4649042/
https://www.ncbi.nlm.nih.gov/pubmed/26636042
http://dx.doi.org/10.3389/fcimb.2015.00080
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author David, Jonathan
Bell, Rachel E.
Clark, Graeme C.
author_facet David, Jonathan
Bell, Rachel E.
Clark, Graeme C.
author_sort David, Jonathan
collection PubMed
description Members of the Burkholderia species can cause a range of severe, often fatal, respiratory diseases. A variety of in vitro models of infection have been developed in an attempt to elucidate the mechanism by which Burkholderia spp. gain entry to and interact with the body. The majority of studies have tended to focus on the interaction of bacteria with phagocytic cells with a paucity of information available with regard to the lung epithelium. However, the lung epithelium is becoming more widely recognized as an important player in innate immunity and the early response to infections. Here we review the complex relationship between Burkholderia species and epithelial cells with an emphasis on the most pathogenic species, Burkholderia pseudomallei and Burkholderia mallei. The current gaps in knowledge in our understanding are highlighted along with the epithelial host-pathogen interactions that offer potential opportunities for therapeutic intervention.
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spelling pubmed-46490422015-12-03 Mechanisms of Disease: Host-Pathogen Interactions between Burkholderia Species and Lung Epithelial Cells David, Jonathan Bell, Rachel E. Clark, Graeme C. Front Cell Infect Microbiol Microbiology Members of the Burkholderia species can cause a range of severe, often fatal, respiratory diseases. A variety of in vitro models of infection have been developed in an attempt to elucidate the mechanism by which Burkholderia spp. gain entry to and interact with the body. The majority of studies have tended to focus on the interaction of bacteria with phagocytic cells with a paucity of information available with regard to the lung epithelium. However, the lung epithelium is becoming more widely recognized as an important player in innate immunity and the early response to infections. Here we review the complex relationship between Burkholderia species and epithelial cells with an emphasis on the most pathogenic species, Burkholderia pseudomallei and Burkholderia mallei. The current gaps in knowledge in our understanding are highlighted along with the epithelial host-pathogen interactions that offer potential opportunities for therapeutic intervention. Frontiers Media S.A. 2015-11-18 /pmc/articles/PMC4649042/ /pubmed/26636042 http://dx.doi.org/10.3389/fcimb.2015.00080 Text en Copyright © 2015 HM Government (United Kingdom). Authors: David, Bell and Clark. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
David, Jonathan
Bell, Rachel E.
Clark, Graeme C.
Mechanisms of Disease: Host-Pathogen Interactions between Burkholderia Species and Lung Epithelial Cells
title Mechanisms of Disease: Host-Pathogen Interactions between Burkholderia Species and Lung Epithelial Cells
title_full Mechanisms of Disease: Host-Pathogen Interactions between Burkholderia Species and Lung Epithelial Cells
title_fullStr Mechanisms of Disease: Host-Pathogen Interactions between Burkholderia Species and Lung Epithelial Cells
title_full_unstemmed Mechanisms of Disease: Host-Pathogen Interactions between Burkholderia Species and Lung Epithelial Cells
title_short Mechanisms of Disease: Host-Pathogen Interactions between Burkholderia Species and Lung Epithelial Cells
title_sort mechanisms of disease: host-pathogen interactions between burkholderia species and lung epithelial cells
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4649042/
https://www.ncbi.nlm.nih.gov/pubmed/26636042
http://dx.doi.org/10.3389/fcimb.2015.00080
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