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Mechanisms of Disease: Host-Pathogen Interactions between Burkholderia Species and Lung Epithelial Cells
Members of the Burkholderia species can cause a range of severe, often fatal, respiratory diseases. A variety of in vitro models of infection have been developed in an attempt to elucidate the mechanism by which Burkholderia spp. gain entry to and interact with the body. The majority of studies have...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2015
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4649042/ https://www.ncbi.nlm.nih.gov/pubmed/26636042 http://dx.doi.org/10.3389/fcimb.2015.00080 |
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author | David, Jonathan Bell, Rachel E. Clark, Graeme C. |
author_facet | David, Jonathan Bell, Rachel E. Clark, Graeme C. |
author_sort | David, Jonathan |
collection | PubMed |
description | Members of the Burkholderia species can cause a range of severe, often fatal, respiratory diseases. A variety of in vitro models of infection have been developed in an attempt to elucidate the mechanism by which Burkholderia spp. gain entry to and interact with the body. The majority of studies have tended to focus on the interaction of bacteria with phagocytic cells with a paucity of information available with regard to the lung epithelium. However, the lung epithelium is becoming more widely recognized as an important player in innate immunity and the early response to infections. Here we review the complex relationship between Burkholderia species and epithelial cells with an emphasis on the most pathogenic species, Burkholderia pseudomallei and Burkholderia mallei. The current gaps in knowledge in our understanding are highlighted along with the epithelial host-pathogen interactions that offer potential opportunities for therapeutic intervention. |
format | Online Article Text |
id | pubmed-4649042 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-46490422015-12-03 Mechanisms of Disease: Host-Pathogen Interactions between Burkholderia Species and Lung Epithelial Cells David, Jonathan Bell, Rachel E. Clark, Graeme C. Front Cell Infect Microbiol Microbiology Members of the Burkholderia species can cause a range of severe, often fatal, respiratory diseases. A variety of in vitro models of infection have been developed in an attempt to elucidate the mechanism by which Burkholderia spp. gain entry to and interact with the body. The majority of studies have tended to focus on the interaction of bacteria with phagocytic cells with a paucity of information available with regard to the lung epithelium. However, the lung epithelium is becoming more widely recognized as an important player in innate immunity and the early response to infections. Here we review the complex relationship between Burkholderia species and epithelial cells with an emphasis on the most pathogenic species, Burkholderia pseudomallei and Burkholderia mallei. The current gaps in knowledge in our understanding are highlighted along with the epithelial host-pathogen interactions that offer potential opportunities for therapeutic intervention. Frontiers Media S.A. 2015-11-18 /pmc/articles/PMC4649042/ /pubmed/26636042 http://dx.doi.org/10.3389/fcimb.2015.00080 Text en Copyright © 2015 HM Government (United Kingdom). Authors: David, Bell and Clark. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Microbiology David, Jonathan Bell, Rachel E. Clark, Graeme C. Mechanisms of Disease: Host-Pathogen Interactions between Burkholderia Species and Lung Epithelial Cells |
title | Mechanisms of Disease: Host-Pathogen Interactions between Burkholderia Species and Lung Epithelial Cells |
title_full | Mechanisms of Disease: Host-Pathogen Interactions between Burkholderia Species and Lung Epithelial Cells |
title_fullStr | Mechanisms of Disease: Host-Pathogen Interactions between Burkholderia Species and Lung Epithelial Cells |
title_full_unstemmed | Mechanisms of Disease: Host-Pathogen Interactions between Burkholderia Species and Lung Epithelial Cells |
title_short | Mechanisms of Disease: Host-Pathogen Interactions between Burkholderia Species and Lung Epithelial Cells |
title_sort | mechanisms of disease: host-pathogen interactions between burkholderia species and lung epithelial cells |
topic | Microbiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4649042/ https://www.ncbi.nlm.nih.gov/pubmed/26636042 http://dx.doi.org/10.3389/fcimb.2015.00080 |
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