Doxorubicin Differentially Induces Apoptosis, Expression of Mitochondrial Apoptosis-Related Genes, and Mitochondrial Potential in BCR-ABL1-Expressing Cells Sensitive and Resistant to Imatinib

Imatinib resistance is an emerging problem in the therapy of chronic myeloid leukemia (CML). Because imatinib induces apoptosis, which may be coupled with mitochondria and DNA damage is a prototype apoptosis-inducing factor, we hypothesized that imatinib-sensitive and -resistant CML cells might diff...

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Detalles Bibliográficos
Autores principales: Synowiec, Ewelina, Hoser, Grazyna, Bialkowska-Warzecha, Jolanta, Pawlowska, Elzbieta, Skorski, Tomasz, Blasiak, Janusz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4649080/
https://www.ncbi.nlm.nih.gov/pubmed/26618175
http://dx.doi.org/10.1155/2015/673512

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