Distinct Processes and Transcriptional Targets Underlie CDX2 Requirements in Intestinal Stem Cells and Differentiated Villus Cells

Lgr5-expressing intestinal stem cells (ISCs) renew the adult gut epithelium by producing mature villus cells (VCs); the transcriptional basis for ISC functions remains unclear. RNA sequencing analysis identified transcripts modulated during differentiation of Lgr5(+) ISCs into VCs, with high express...

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Detalles Bibliográficos
Autores principales: San Roman, Adrianna K., Tovaglieri, Alessio, Breault, David T., Shivdasani, Ramesh A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4649135/
https://www.ncbi.nlm.nih.gov/pubmed/26489894
http://dx.doi.org/10.1016/j.stemcr.2015.09.006

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