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Strong inhibition of TNF-α production and inhibition of IL-8 and COX-2 mRNA expression in monocyte-derived macrophages by RWJ 67657, a p38 mitogen-activated protein kinase (MAPK) inhibitor

In inflammatory processes, the p38 mitogen-activated protein kinase (MAPK) signal transduction route regulates production and expression of cytokines and other inflammatory mediators. Tumor necrosis factor α (TNF-α) is a pivotal cytokine in rheumatoid arthritis and its production in macrophages is u...

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Detalles Bibliográficos
Autores principales:	Westra, Johanna, Doornbos-van der Meer, Berber, de Boer, Peter, van Leeuwen, Miek A, van Rijswijk, Martin H, Limburg, Pieter C
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2004
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC464924/ https://www.ncbi.nlm.nih.gov/pubmed/15225374 http://dx.doi.org/10.1186/ar1204

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