Intrauterine Bone Marrow Transplantation in Osteogenesis Imperfecta Mice Yields Donor Osteoclasts and Osteomacs but Not Osteoblasts

• The goal of osteogenesis imperfecta (OI) cell therapy is osteoblast replacement; • In utero transplantation (IUT) of bone marrow was conducted in OI mice; • Donor-derived osteoblasts were absent following bone marrow IUT; • Donor-derived hematopoietic cells included osteoclasts and osteal macropha...

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Autores principales: Millard, Susan M., Pettit, Allison R., Ellis, Rebecca, Chan, Jerry K.Y., Raggatt, Liza J., Khosrotehrani, Kiarash, Fisk, Nicholas M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4649292/
https://www.ncbi.nlm.nih.gov/pubmed/26527386
http://dx.doi.org/10.1016/j.stemcr.2015.09.017
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author Millard, Susan M.
Pettit, Allison R.
Ellis, Rebecca
Chan, Jerry K.Y.
Raggatt, Liza J.
Khosrotehrani, Kiarash
Fisk, Nicholas M.
author_facet Millard, Susan M.
Pettit, Allison R.
Ellis, Rebecca
Chan, Jerry K.Y.
Raggatt, Liza J.
Khosrotehrani, Kiarash
Fisk, Nicholas M.
author_sort Millard, Susan M.
collection PubMed
description • The goal of osteogenesis imperfecta (OI) cell therapy is osteoblast replacement; • In utero transplantation (IUT) of bone marrow was conducted in OI mice; • Donor-derived osteoblasts were absent following bone marrow IUT; • Donor-derived hematopoietic cells included osteoclasts and osteal macrophages.
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spelling pubmed-46492922015-12-11 Intrauterine Bone Marrow Transplantation in Osteogenesis Imperfecta Mice Yields Donor Osteoclasts and Osteomacs but Not Osteoblasts Millard, Susan M. Pettit, Allison R. Ellis, Rebecca Chan, Jerry K.Y. Raggatt, Liza J. Khosrotehrani, Kiarash Fisk, Nicholas M. Stem Cell Reports Report • The goal of osteogenesis imperfecta (OI) cell therapy is osteoblast replacement; • In utero transplantation (IUT) of bone marrow was conducted in OI mice; • Donor-derived osteoblasts were absent following bone marrow IUT; • Donor-derived hematopoietic cells included osteoclasts and osteal macrophages. Elsevier 2015-10-29 /pmc/articles/PMC4649292/ /pubmed/26527386 http://dx.doi.org/10.1016/j.stemcr.2015.09.017 Text en © 2015 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Report
Millard, Susan M.
Pettit, Allison R.
Ellis, Rebecca
Chan, Jerry K.Y.
Raggatt, Liza J.
Khosrotehrani, Kiarash
Fisk, Nicholas M.
Intrauterine Bone Marrow Transplantation in Osteogenesis Imperfecta Mice Yields Donor Osteoclasts and Osteomacs but Not Osteoblasts
title Intrauterine Bone Marrow Transplantation in Osteogenesis Imperfecta Mice Yields Donor Osteoclasts and Osteomacs but Not Osteoblasts
title_full Intrauterine Bone Marrow Transplantation in Osteogenesis Imperfecta Mice Yields Donor Osteoclasts and Osteomacs but Not Osteoblasts
title_fullStr Intrauterine Bone Marrow Transplantation in Osteogenesis Imperfecta Mice Yields Donor Osteoclasts and Osteomacs but Not Osteoblasts
title_full_unstemmed Intrauterine Bone Marrow Transplantation in Osteogenesis Imperfecta Mice Yields Donor Osteoclasts and Osteomacs but Not Osteoblasts
title_short Intrauterine Bone Marrow Transplantation in Osteogenesis Imperfecta Mice Yields Donor Osteoclasts and Osteomacs but Not Osteoblasts
title_sort intrauterine bone marrow transplantation in osteogenesis imperfecta mice yields donor osteoclasts and osteomacs but not osteoblasts
topic Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4649292/
https://www.ncbi.nlm.nih.gov/pubmed/26527386
http://dx.doi.org/10.1016/j.stemcr.2015.09.017
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