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Seizure activity results in calcium- and mitochondria-independent ROS production via NADPH and xanthine oxidase activation
Seizure activity has been proposed to result in the generation of reactive oxygen species (ROS), which then contribute to seizure-induced neuronal damage and eventually cell death. Although the mechanisms of seizure-induced ROS generation are unclear, mitochondria and cellular calcium overload have...
Autores principales: | Kovac, S, Domijan, A-M, Walker, M C, Abramov, A Y |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4649505/ https://www.ncbi.nlm.nih.gov/pubmed/25275601 http://dx.doi.org/10.1038/cddis.2014.390 |
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