Gefitinib targets ZAP-70-expressing chronic lymphocytic leukemia cells and inhibits B-cell receptor signaling

Chronic lymphocytic leukemia (CLL) can be divided into groups based on biomarkers of poor prognosis. The expression of the tyrosine kinase ZAP-70 (member of the Syk tyrosine kinase family) in CLL cells is associated with shorter overall survival in CLL patients. Currently, there is a lack of targete...

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Detalles Bibliográficos
Autores principales: Dielschneider, R F, Xiao, W, Yoon, J-Y, Noh, E, Banerji, V, Li, H, Marshall, A J, Johnston, J B, Gibson, S B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4649506/
https://www.ncbi.nlm.nih.gov/pubmed/25275600
http://dx.doi.org/10.1038/cddis.2014.391

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4649506/
https://www.ncbi.nlm.nih.gov/pubmed/25275600
http://dx.doi.org/10.1038/cddis.2014.391

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