Nanoencapsulation of ABT-737 and camptothecin enhances their clinical potential through synergistic antitumor effects and reduction of systemic toxicity

The simultaneous delivery of multiple cancer drugs in combination therapies to achieve optimal therapeutic effects in patients can be challenging. This study investigated whether co-encapsulation of the BH3-mimetic ABT-737 and the topoisomerase I inhibitor camptothecin (CPT) in PEGylated polymeric n...

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Detalles Bibliográficos
Autores principales: Schmid, D, Jarvis, G E, Fay, F, Small, D M, Greene, M K, Majkut, J, Spence, S, McLaughlin, K M, McCloskey, K D, Johnston, P G, Kissenpfennig, A, Longley, D B, Scott, C J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4649518/
https://www.ncbi.nlm.nih.gov/pubmed/25299779
http://dx.doi.org/10.1038/cddis.2014.413

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4649518/
https://www.ncbi.nlm.nih.gov/pubmed/25299779
http://dx.doi.org/10.1038/cddis.2014.413

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