Glutathione depletion sensitizes cisplatin- and temozolomide-resistant glioma cells in vitro and in vivo

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Malignant glioma is a severe type of brain tumor with a poor prognosis and few options for therapy. The main chemotherapy protocol for this type of tumor is based on temozolomide (TMZ), albeit with limited success. Cisplatin is widely used to treat several types of tumor and, in association with TMZ...

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Detalles Bibliográficos
Autores principales: Rocha, C R R, Garcia, C C M, Vieira, D B, Quinet, A, de Andrade-Lima, L C, Munford, V, Belizário, J E, Menck, C F M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4649538/
https://www.ncbi.nlm.nih.gov/pubmed/25356874
http://dx.doi.org/10.1038/cddis.2014.465

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