Histone deacetylase 3 inhibition re-establishes synaptic tagging and capture in aging through the activation of nuclear factor kappa B

Aging is associated with impaired plasticity and memory. Altered epigenetic mechanisms are implicated in the impairment of memory with advanced aging. Histone deacetylase 3 (HDAC3) is an important negative regulator of memory. However, the role of HDAC3 in aged neural networks is not well establishe...

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Detalles Bibliográficos
Autores principales: Sharma, Mahima, Shivarama Shetty, Mahesh, Arumugam, Thiruma Valavan, Sajikumar, Sreedharan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4649608/
https://www.ncbi.nlm.nih.gov/pubmed/26577291
http://dx.doi.org/10.1038/srep16616

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