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Dependence of Human Colorectal Cells Lacking the FBW7 Tumor Suppressor on the Spindle Assembly Checkpoint

FBW7 (F-box and WD repeat domain containing 7), also known as FBXW7 or hCDC4, is a tumor suppressor gene mutated in a broad spectrum of cancer cell types. As a component of the SCF E3 ubiquitin ligase, FBW7 is responsible for specifically recognizing phosphorylated substrates, many important for tum...

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Detalles Bibliográficos
Autores principales:	Bailey, Melanie L., Singh, Tejomayee, Mero, Patricia, Moffat, Jason, Hieter, Philip
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Genetics Society of America 2015
Materias:	Investigations
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4649658/ https://www.ncbi.nlm.nih.gov/pubmed/26354767 http://dx.doi.org/10.1534/genetics.115.180653

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