Apoptosome activation, an important molecular instigator in 6-mercaptopurine induced Leydig cell death

Leydig cells are crucial to the production of testosterone in males. It is unknown if the cancer chemotherapeutic drug, 6-mercaptopurine (6 MP), produces Leydig cell failure among adult survivors of childhood acute lymphoblastic leukemia. Moreover, it is not known whether Leydig cell failure is due...

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Detalles Bibliográficos
Autores principales: Morgan, Jessica A., Lynch, John, Panetta, John C., Wang, Yao, Frase, Sharon, Bao, Ju, Zheng, Jie, Opferman, Joseph T., Janke, Laura, Green, Daniel M., Chemaitilly, Wassim, Schuetz, John D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4649703/
https://www.ncbi.nlm.nih.gov/pubmed/26576726
http://dx.doi.org/10.1038/srep16488

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