Preferential Extracellular Generation of the Active Parkinsonian Toxin MPP(+) by Transporter-Independent Export of the Intermediate MPDP(+)

Aims: 1-Methyl-4-phenyl-tetrahydropyridine (MPTP) is among the most widely used neurotoxins for inducing experimental parkinsonism. MPTP causes parkinsonian symptoms in mice, primates, and humans by killing a subpopulation of dopaminergic neurons. Extrapolations of data obtained using MPTP-based par...

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Detalles Bibliográficos
Autores principales: Schildknecht, Stefan, Pape, Regina, Meiser, Johannes, Karreman, Christiaan, Strittmatter, Tobias, Odermatt, Meike, Cirri, Erica, Friemel, Anke, Ringwald, Markus, Pasquarelli, Noemi, Ferger, Boris, Brunner, Thomas, Marx, Andreas, Möller, Heiko M., Hiller, Karsten, Leist, Marcel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mary Ann Liebert, Inc. 2015
Materias:
Original Research Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4649766/
https://www.ncbi.nlm.nih.gov/pubmed/26413876
http://dx.doi.org/10.1089/ars.2015.6297

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