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Seasonal Affective Disorder (SAD): Role of Lamotrigine Augmentation to Anti-Depressant Medication in Winter Depression

BACKGROUND: Many therapeutic options have been evaluated and tried for seasonal affective disorder (SAD) including bright light therapy (BLT), anti-depressants, beta-blockers and psychotherapy, but the data supporting use of mood-stabilizing agents is just handful in spite of this condition being un...

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Autores principales: Hussain, Arshad, Shah, Majid Shafi, Roub, Fazl E, Dar, Mansoor Ahmad, Wani, Zaid Ahmad, Jan, Mohd Muzzaffar, Wani, Rayees Ahmad, Bhat, Tariq Ahmad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4649817/
https://www.ncbi.nlm.nih.gov/pubmed/26664074
http://dx.doi.org/10.4103/0253-7176.162916
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author Hussain, Arshad
Shah, Majid Shafi
Roub, Fazl E
Dar, Mansoor Ahmad
Wani, Zaid Ahmad
Jan, Mohd Muzzaffar
Wani, Rayees Ahmad
Bhat, Tariq Ahmad
author_facet Hussain, Arshad
Shah, Majid Shafi
Roub, Fazl E
Dar, Mansoor Ahmad
Wani, Zaid Ahmad
Jan, Mohd Muzzaffar
Wani, Rayees Ahmad
Bhat, Tariq Ahmad
author_sort Hussain, Arshad
collection PubMed
description BACKGROUND: Many therapeutic options have been evaluated and tried for seasonal affective disorder (SAD) including bright light therapy (BLT), anti-depressants, beta-blockers and psychotherapy, but the data supporting use of mood-stabilizing agents is just handful in spite of this condition being understood most frequently to be associated with bipolar affective disorder II (BPAD II). So we planned to study role of Lamotrigine (Mood stabilizing agent) in SAD. MATERIALS AND METHODS: 30 patients of SAD who were prescribed lamotrigine in addition to antidepressant medications for a minimum of 8 weeks and were assessed for severity using HAM-D were selected retrospectively from the hospital records for this study. HAM-D scores at 2, 4 and 8 weeks were compared to baseline scores. STATISTICS ANALYSIS: Single tailed t-test was used to study the difference of means to assess the therapeutic response and pre/post analysis of change. Statistical significance was set at P < 0.05. RESULTS: Though no significant difference was seen in HAM-D Scores at 2 weeks of treatment compared to baseline, but results were statistically significant at 4 and 8 weeks of treatment with lamotrigine augmentation of antidepressant medications. CONCLUSION: We conclude that lamotrigine augmentation was found to be effective treatment strategy for managing winter depression phase of Seasonal Affective Disorder.
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spelling pubmed-46498172015-12-10 Seasonal Affective Disorder (SAD): Role of Lamotrigine Augmentation to Anti-Depressant Medication in Winter Depression Hussain, Arshad Shah, Majid Shafi Roub, Fazl E Dar, Mansoor Ahmad Wani, Zaid Ahmad Jan, Mohd Muzzaffar Wani, Rayees Ahmad Bhat, Tariq Ahmad Indian J Psychol Med Original Article BACKGROUND: Many therapeutic options have been evaluated and tried for seasonal affective disorder (SAD) including bright light therapy (BLT), anti-depressants, beta-blockers and psychotherapy, but the data supporting use of mood-stabilizing agents is just handful in spite of this condition being understood most frequently to be associated with bipolar affective disorder II (BPAD II). So we planned to study role of Lamotrigine (Mood stabilizing agent) in SAD. MATERIALS AND METHODS: 30 patients of SAD who were prescribed lamotrigine in addition to antidepressant medications for a minimum of 8 weeks and were assessed for severity using HAM-D were selected retrospectively from the hospital records for this study. HAM-D scores at 2, 4 and 8 weeks were compared to baseline scores. STATISTICS ANALYSIS: Single tailed t-test was used to study the difference of means to assess the therapeutic response and pre/post analysis of change. Statistical significance was set at P < 0.05. RESULTS: Though no significant difference was seen in HAM-D Scores at 2 weeks of treatment compared to baseline, but results were statistically significant at 4 and 8 weeks of treatment with lamotrigine augmentation of antidepressant medications. CONCLUSION: We conclude that lamotrigine augmentation was found to be effective treatment strategy for managing winter depression phase of Seasonal Affective Disorder. Medknow Publications & Media Pvt Ltd 2015 /pmc/articles/PMC4649817/ /pubmed/26664074 http://dx.doi.org/10.4103/0253-7176.162916 Text en Copyright: © Indian Journal of Psychological Medicine http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Hussain, Arshad
Shah, Majid Shafi
Roub, Fazl E
Dar, Mansoor Ahmad
Wani, Zaid Ahmad
Jan, Mohd Muzzaffar
Wani, Rayees Ahmad
Bhat, Tariq Ahmad
Seasonal Affective Disorder (SAD): Role of Lamotrigine Augmentation to Anti-Depressant Medication in Winter Depression
title Seasonal Affective Disorder (SAD): Role of Lamotrigine Augmentation to Anti-Depressant Medication in Winter Depression
title_full Seasonal Affective Disorder (SAD): Role of Lamotrigine Augmentation to Anti-Depressant Medication in Winter Depression
title_fullStr Seasonal Affective Disorder (SAD): Role of Lamotrigine Augmentation to Anti-Depressant Medication in Winter Depression
title_full_unstemmed Seasonal Affective Disorder (SAD): Role of Lamotrigine Augmentation to Anti-Depressant Medication in Winter Depression
title_short Seasonal Affective Disorder (SAD): Role of Lamotrigine Augmentation to Anti-Depressant Medication in Winter Depression
title_sort seasonal affective disorder (sad): role of lamotrigine augmentation to anti-depressant medication in winter depression
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4649817/
https://www.ncbi.nlm.nih.gov/pubmed/26664074
http://dx.doi.org/10.4103/0253-7176.162916
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