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RIPK1 promotes death receptor-independent caspase-8-mediated apoptosis under unresolved ER stress conditions
Accumulation of unfolded proteins in the endoplasmic reticulum (ER) causes ER stress and results in the activation of the unfolded protein response (UPR), which aims at restoring ER homeostasis. However, when the stress is too severe the UPR switches from being a pro-survival response to a pro-death...
Autores principales: | Estornes, Y, Aguileta, M A, Dubuisson, C, De Keyser, J, Goossens, V, Kersse, K, Samali, A, Vandenabeele, P, Bertrand, M J M |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4649839/ https://www.ncbi.nlm.nih.gov/pubmed/25476903 http://dx.doi.org/10.1038/cddis.2014.523 |
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