RIPK1 promotes death receptor-independent caspase-8-mediated apoptosis under unresolved ER stress conditions

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Accumulation of unfolded proteins in the endoplasmic reticulum (ER) causes ER stress and results in the activation of the unfolded protein response (UPR), which aims at restoring ER homeostasis. However, when the stress is too severe the UPR switches from being a pro-survival response to a pro-death...

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Detalles Bibliográficos
Autores principales: Estornes, Y, Aguileta, M A, Dubuisson, C, De Keyser, J, Goossens, V, Kersse, K, Samali, A, Vandenabeele, P, Bertrand, M J M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4649839/
https://www.ncbi.nlm.nih.gov/pubmed/25476903
http://dx.doi.org/10.1038/cddis.2014.523
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