XIAP-targeting drugs re-sensitize PIK3CA-mutated colorectal cancer cells for death receptor-induced apoptosis

Mutations in the oncogenic PIK3CA gene are found in 10–20% of colorectal cancers (CRCs) and are associated with poor prognosis. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and agonistic TRAIL death receptor antibodies emerged as promising anti-neoplastic therapeutics, but to date...

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Detalles Bibliográficos
Autores principales: Ehrenschwender, M, Bittner, S, Seibold, K, Wajant, H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4649844/
https://www.ncbi.nlm.nih.gov/pubmed/25501831
http://dx.doi.org/10.1038/cddis.2014.534

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4649844/
https://www.ncbi.nlm.nih.gov/pubmed/25501831
http://dx.doi.org/10.1038/cddis.2014.534

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