Protective Role of Oleuropein against Acute Deltamethrin-Induced Neurotoxicity in Rat Brain

BACKGROUND: Deltamethrin (DM) is a synthetic pyrethroid insecticide that can elicit neurotoxicity, leading to apoptosis. There is accumulating evidence that oleuropein (OE) has anti-apoptotic effect. The purpose of this study was to determine the anti-apoptotic effect of OE pretreatment in the neuro...

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Detalles Bibliográficos
Autores principales: Khalatbary, Ali Reza, Ghaffari, Elmira, Mohammadnegad, Behrooz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Pasteur Institute of Iran 2015
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4649861/
https://www.ncbi.nlm.nih.gov/pubmed/26216399
http://dx.doi.org/10.7508/ibj.2015.04.009
Descripción
Sumario:BACKGROUND: Deltamethrin (DM) is a synthetic pyrethroid insecticide that can elicit neurotoxicity, leading to apoptosis. There is accumulating evidence that oleuropein (OE) has anti-apoptotic effect. The purpose of this study was to determine the anti-apoptotic effect of OE pretreatment in the neuronal cells of cerebral cortex. METHODS: Rats were randomly divided into four groups each containing five rats: DM-treated group (12.5 mg/kg, a single dose), OE-treated group (20 mg/kg per day), DM + OE-treated group, and vehicle group. Sections of the brain were obtained 24 hours after DM injection and studied for histopathological and immunohistochemistry assessment. RESULTS: The histopathological assessments showed lesser characteristics of neural degeneration in DM + OE group compared with DM group. Greater Bcl-2 and attenuated Bax expression could be detected in the DM + OE treated-mice compared with DM group. CONCLUSION: The results suggested that DM-induced neurotoxicity can be subsided by OE.

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