Ovarian mucinous adenocarcinoma with functioning stroma in postmenopausal women: aromatase and SF-1 expressions

BACKGROUND: A high serum estradiol (E2) level is occasionally detected in postmenopausal women with common epithelial ovarian tumors with functioning stroma. It has been proven that functioning stroma has the capacity to convert androgens to estrogens. However, the mechanism of the initiation and de...

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Autores principales: Hattori, Yuka, Yamada, Shizuka, Yamamoto, Makoto, Orisaka, Makoto, Mizutani, Tetsuya, Yoshida, Yoshio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4650118/
https://www.ncbi.nlm.nih.gov/pubmed/26576867
http://dx.doi.org/10.1186/s13048-015-0202-y
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author Hattori, Yuka
Yamada, Shizuka
Yamamoto, Makoto
Orisaka, Makoto
Mizutani, Tetsuya
Yoshida, Yoshio
author_facet Hattori, Yuka
Yamada, Shizuka
Yamamoto, Makoto
Orisaka, Makoto
Mizutani, Tetsuya
Yoshida, Yoshio
author_sort Hattori, Yuka
collection PubMed
description BACKGROUND: A high serum estradiol (E2) level is occasionally detected in postmenopausal women with common epithelial ovarian tumors with functioning stroma. It has been proven that functioning stroma has the capacity to convert androgens to estrogens. However, the mechanism of the initiation and development of functioning stroma remains unclear. CASE PRESENTATION: We present two cases of elevated E2 levels in elderly women with ovarian mucinous adenocarcinomas that contained functioning stroma. Immunohistochemical evaluation revealed high expression levels of aromatase and steroidogenic factor-1 (SF-1), which is considered to be a master regulator of steroidogenesis, in their ovarian stroma. CONCLUSIONS: These cases suggest that overexpression of SF-1 may promote estrogen biosynthesis through regulation of P450 aromatase expression in ovarian tumors with functioning stroma; this in turn induces high serum E2 levels in postmenopausal women with common epithelial ovarian tumors.
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spelling pubmed-46501182015-11-19 Ovarian mucinous adenocarcinoma with functioning stroma in postmenopausal women: aromatase and SF-1 expressions Hattori, Yuka Yamada, Shizuka Yamamoto, Makoto Orisaka, Makoto Mizutani, Tetsuya Yoshida, Yoshio J Ovarian Res Case Report BACKGROUND: A high serum estradiol (E2) level is occasionally detected in postmenopausal women with common epithelial ovarian tumors with functioning stroma. It has been proven that functioning stroma has the capacity to convert androgens to estrogens. However, the mechanism of the initiation and development of functioning stroma remains unclear. CASE PRESENTATION: We present two cases of elevated E2 levels in elderly women with ovarian mucinous adenocarcinomas that contained functioning stroma. Immunohistochemical evaluation revealed high expression levels of aromatase and steroidogenic factor-1 (SF-1), which is considered to be a master regulator of steroidogenesis, in their ovarian stroma. CONCLUSIONS: These cases suggest that overexpression of SF-1 may promote estrogen biosynthesis through regulation of P450 aromatase expression in ovarian tumors with functioning stroma; this in turn induces high serum E2 levels in postmenopausal women with common epithelial ovarian tumors. BioMed Central 2015-11-14 /pmc/articles/PMC4650118/ /pubmed/26576867 http://dx.doi.org/10.1186/s13048-015-0202-y Text en © Hattori et al. 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Case Report
Hattori, Yuka
Yamada, Shizuka
Yamamoto, Makoto
Orisaka, Makoto
Mizutani, Tetsuya
Yoshida, Yoshio
Ovarian mucinous adenocarcinoma with functioning stroma in postmenopausal women: aromatase and SF-1 expressions
title Ovarian mucinous adenocarcinoma with functioning stroma in postmenopausal women: aromatase and SF-1 expressions
title_full Ovarian mucinous adenocarcinoma with functioning stroma in postmenopausal women: aromatase and SF-1 expressions
title_fullStr Ovarian mucinous adenocarcinoma with functioning stroma in postmenopausal women: aromatase and SF-1 expressions
title_full_unstemmed Ovarian mucinous adenocarcinoma with functioning stroma in postmenopausal women: aromatase and SF-1 expressions
title_short Ovarian mucinous adenocarcinoma with functioning stroma in postmenopausal women: aromatase and SF-1 expressions
title_sort ovarian mucinous adenocarcinoma with functioning stroma in postmenopausal women: aromatase and sf-1 expressions
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4650118/
https://www.ncbi.nlm.nih.gov/pubmed/26576867
http://dx.doi.org/10.1186/s13048-015-0202-y
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