BAC transgenic mice provide evidence that p53 expression is highly regulated in vivo

p53 is an important tumor suppressor and stress response mediator. Proper control of p53 level and activity is tightly associated with its function. Posttranslational modifications and the interactions with Mdm2 and Mdm4 are major mechanisms controlling p53 activity and stability. As p53 protein is...

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Detalles Bibliográficos
Autores principales: Chen, L, Zhang, G X, Zhou, Y, Zhang, C X, Xie, Y Y, Xiang, C, He, X Y, Zhang, Q, Liu, G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4650433/
https://www.ncbi.nlm.nih.gov/pubmed/26379189
http://dx.doi.org/10.1038/cddis.2015.224

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