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Serum lipid profiles: novel biomarkers predicting advanced prostate cancer in patients receiving radical prostatectomy
This study aimed to evaluate the role of serum lipid profiles as novel biomarkers in predicting pathological characteristics of prostate cancer (PCa). We retrospectively analyzed 322 consecutive patients with clinically localized PCa receiving radical prostatectomy (RP) and extended pelvic lymphaden...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4650485/ https://www.ncbi.nlm.nih.gov/pubmed/25475662 http://dx.doi.org/10.4103/1008-682X.142135 |
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author | Zhang, Gui-Ming Qin, Xiao-Jian Zhang, Hai-Liang Xiao, Wen-Jun Zhu, Yao Gu, Cheng-Yuan Dai, Bo Shi, Guo-Hai Ye, Ding-Wei |
author_facet | Zhang, Gui-Ming Qin, Xiao-Jian Zhang, Hai-Liang Xiao, Wen-Jun Zhu, Yao Gu, Cheng-Yuan Dai, Bo Shi, Guo-Hai Ye, Ding-Wei |
author_sort | Zhang, Gui-Ming |
collection | PubMed |
description | This study aimed to evaluate the role of serum lipid profiles as novel biomarkers in predicting pathological characteristics of prostate cancer (PCa). We retrospectively analyzed 322 consecutive patients with clinically localized PCa receiving radical prostatectomy (RP) and extended pelvic lymphadenectomy. Unconditional logistic regression was used to estimate the prostatectomy Gleason score (pGS), pathological stage and lymph node involvement (LNI) in RP specimens. Preoperative prostate-specific antigen (PSA) levels, biopsy GS (bGS), and preoperative tumor, node, metastasis staging were used as basic variables to predict postoperative pathological characteristics. Preoperative serum lipid profiles were introduced as potential predictors. A receiver operating characteristic (ROC) curve was used to determine predictive efficacy. Significant differences in pathological characteristics were observed among patients with normal and abnormal total cholesterol (TC), triglyceride (TG), and low-density lipoprotein (LDL) levels, with the exception of pGS in the TG group. Multivariable regression analysis revealed that the odds ratio for high levels of TC for LNI compared with normal TC levels was 6.386 (95% confidence interval [CI] 1.510–27.010), 3.270 (95% CI: 1.470–7.278) for high levels of TG for pT3–4 disease, and 2.670 (95% CI: 1.134–6.287) for high levels of LDL for pGS. The area under the ROC curve of the models with dyslipidemia was larger than that in models without dyslipidemia, in predicting pathological characteristics. Abnormal TC, TG, and LDL levels are significantly associated with postoperative pathological status in PCa patients. Together with preoperative PSA levels, bGS, and clinical stage, dyslipidemia is more accurate in predicting pathological characteristics. |
format | Online Article Text |
id | pubmed-4650485 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-46504852015-12-10 Serum lipid profiles: novel biomarkers predicting advanced prostate cancer in patients receiving radical prostatectomy Zhang, Gui-Ming Qin, Xiao-Jian Zhang, Hai-Liang Xiao, Wen-Jun Zhu, Yao Gu, Cheng-Yuan Dai, Bo Shi, Guo-Hai Ye, Ding-Wei Asian J Androl Original Article This study aimed to evaluate the role of serum lipid profiles as novel biomarkers in predicting pathological characteristics of prostate cancer (PCa). We retrospectively analyzed 322 consecutive patients with clinically localized PCa receiving radical prostatectomy (RP) and extended pelvic lymphadenectomy. Unconditional logistic regression was used to estimate the prostatectomy Gleason score (pGS), pathological stage and lymph node involvement (LNI) in RP specimens. Preoperative prostate-specific antigen (PSA) levels, biopsy GS (bGS), and preoperative tumor, node, metastasis staging were used as basic variables to predict postoperative pathological characteristics. Preoperative serum lipid profiles were introduced as potential predictors. A receiver operating characteristic (ROC) curve was used to determine predictive efficacy. Significant differences in pathological characteristics were observed among patients with normal and abnormal total cholesterol (TC), triglyceride (TG), and low-density lipoprotein (LDL) levels, with the exception of pGS in the TG group. Multivariable regression analysis revealed that the odds ratio for high levels of TC for LNI compared with normal TC levels was 6.386 (95% confidence interval [CI] 1.510–27.010), 3.270 (95% CI: 1.470–7.278) for high levels of TG for pT3–4 disease, and 2.670 (95% CI: 1.134–6.287) for high levels of LDL for pGS. The area under the ROC curve of the models with dyslipidemia was larger than that in models without dyslipidemia, in predicting pathological characteristics. Abnormal TC, TG, and LDL levels are significantly associated with postoperative pathological status in PCa patients. Together with preoperative PSA levels, bGS, and clinical stage, dyslipidemia is more accurate in predicting pathological characteristics. Medknow Publications & Media Pvt Ltd 2015 2014-11-21 /pmc/articles/PMC4650485/ /pubmed/25475662 http://dx.doi.org/10.4103/1008-682X.142135 Text en Copyright: © Asian Journal of Andrology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Zhang, Gui-Ming Qin, Xiao-Jian Zhang, Hai-Liang Xiao, Wen-Jun Zhu, Yao Gu, Cheng-Yuan Dai, Bo Shi, Guo-Hai Ye, Ding-Wei Serum lipid profiles: novel biomarkers predicting advanced prostate cancer in patients receiving radical prostatectomy |
title | Serum lipid profiles: novel biomarkers predicting advanced prostate cancer in patients receiving radical prostatectomy |
title_full | Serum lipid profiles: novel biomarkers predicting advanced prostate cancer in patients receiving radical prostatectomy |
title_fullStr | Serum lipid profiles: novel biomarkers predicting advanced prostate cancer in patients receiving radical prostatectomy |
title_full_unstemmed | Serum lipid profiles: novel biomarkers predicting advanced prostate cancer in patients receiving radical prostatectomy |
title_short | Serum lipid profiles: novel biomarkers predicting advanced prostate cancer in patients receiving radical prostatectomy |
title_sort | serum lipid profiles: novel biomarkers predicting advanced prostate cancer in patients receiving radical prostatectomy |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4650485/ https://www.ncbi.nlm.nih.gov/pubmed/25475662 http://dx.doi.org/10.4103/1008-682X.142135 |
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