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Is RANKL inhibition both anti-resorptive and anabolic in rheumatoid arthritis?
A small peptide, OP3-4, blocks receptor activator of NF-κB from binding to its ligand, receptor activator of NF-κB ligand (RANKL), and was reported recently to inhibit bone resorption, promote bone formation and protect cartilage in a preclinical rheumatoid arthritis model. The latter effects may re...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4650503/ https://www.ncbi.nlm.nih.gov/pubmed/26577945 http://dx.doi.org/10.1186/s13075-015-0861-5 |