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Loss of Caspase-3 sensitizes colon cancer cells to genotoxic stress via RIP1-dependent necrosis

Caspase-3 is the best known executioner caspase in apoptosis. We generated caspase-3 knockout (C3KO) and knockdown human colorectal cancer cells, and found that they are unexpectedly sensitized to DNA-damaging agents including 5-fluorouracil (5-FU), etoposide, and camptothecin. C3KO xenograft tumors...

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Detalles Bibliográficos
Autores principales:	Brown, M F, Leibowitz, B J, Chen, D, He, K, Zou, F, Sobol, R W, Beer-Stolz, D, Zhang, L, Yu, J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4650537/ https://www.ncbi.nlm.nih.gov/pubmed/25906152 http://dx.doi.org/10.1038/cddis.2015.104

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