Acquisition of meiotic DNA repair regulators maintain genome stability in glioblastoma

Glioblastoma (GBM), the most prevalent type of primary intrinsic brain cancer in adults, remains universally fatal despite maximal therapy, including radiotherapy and chemotherapy. Cytotoxic therapy generates double-stranded DNA breaks (DSBs), most commonly repaired by homologous recombination (HR)....

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Detalles Bibliográficos
Autores principales: Rivera, M, Wu, Q, Hamerlik, P, Hjelmeland, A B, Bao, S, Rich, J N
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4650544/
https://www.ncbi.nlm.nih.gov/pubmed/25906155
http://dx.doi.org/10.1038/cddis.2015.75

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