Myeloid lineage skewing due to exacerbated NF-κB signaling facilitates osteopenia in Scurfy mice

Immune surveillance through Foxp3+ regulatory T cells plays a crucial role in bone homeostasis. Scurfy, the mouse model of autoimmune IPEX syndrome, bears a loss-of-function mutation in Foxp3 that leads to multi-organ inflammation. Herein, we report that scurfy mice exhibit severe bone loss mediated...

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Detalles Bibliográficos
Autores principales: Chen, T H-P, Swarnkar, G, Mbalaviele, G, Abu-Amer, Y
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4650554/
https://www.ncbi.nlm.nih.gov/pubmed/25880090
http://dx.doi.org/10.1038/cddis.2015.87

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4650554/
https://www.ncbi.nlm.nih.gov/pubmed/25880090
http://dx.doi.org/10.1038/cddis.2015.87

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