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Myeloid lineage skewing due to exacerbated NF-κB signaling facilitates osteopenia in Scurfy mice
Immune surveillance through Foxp3+ regulatory T cells plays a crucial role in bone homeostasis. Scurfy, the mouse model of autoimmune IPEX syndrome, bears a loss-of-function mutation in Foxp3 that leads to multi-organ inflammation. Herein, we report that scurfy mice exhibit severe bone loss mediated...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4650554/ https://www.ncbi.nlm.nih.gov/pubmed/25880090 http://dx.doi.org/10.1038/cddis.2015.87 |