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Discovery of the migrasome, an organelle mediating release of cytoplasmic contents during cell migration
Cells communicate with each other through secreting and releasing proteins and vesicles. Many cells can migrate. In this study, we report the discovery of migracytosis, a cell migration-dependent mechanism for releasing cellular contents, and migrasomes, the vesicular structures that mediate migracy...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4650581/ https://www.ncbi.nlm.nih.gov/pubmed/25342562 http://dx.doi.org/10.1038/cr.2014.135 |
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author | Ma, Liang Li, Ying Peng, Junya Wu, Danni Zhao, Xiaoxin Cui, Yitong Chen, Lilian Yan, Xiaojun Du, Yanan Yu, Li |
author_facet | Ma, Liang Li, Ying Peng, Junya Wu, Danni Zhao, Xiaoxin Cui, Yitong Chen, Lilian Yan, Xiaojun Du, Yanan Yu, Li |
author_sort | Ma, Liang |
collection | PubMed |
description | Cells communicate with each other through secreting and releasing proteins and vesicles. Many cells can migrate. In this study, we report the discovery of migracytosis, a cell migration-dependent mechanism for releasing cellular contents, and migrasomes, the vesicular structures that mediate migracytosis. As migrating cells move, they leave long tubular strands, called retraction fibers, behind them. Large vesicles, which contain numerous smaller vesicles, grow on the tips and intersections of retraction fibers. These fibers, which connect the vesicles with the main cell body, eventually break, and the vesicles are released into the extracellular space or directly taken up by surrounding cells. Since the formation of these vesicles is migration-dependent, we named them “migrasomes”. We also found that cytosolic contents can be transported into migrasomes and released from the cell through migrasomes. We named this migration-dependent release mechanism “migracytosis”. |
format | Online Article Text |
id | pubmed-4650581 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-46505812015-12-01 Discovery of the migrasome, an organelle mediating release of cytoplasmic contents during cell migration Ma, Liang Li, Ying Peng, Junya Wu, Danni Zhao, Xiaoxin Cui, Yitong Chen, Lilian Yan, Xiaojun Du, Yanan Yu, Li Cell Res Original Article Cells communicate with each other through secreting and releasing proteins and vesicles. Many cells can migrate. In this study, we report the discovery of migracytosis, a cell migration-dependent mechanism for releasing cellular contents, and migrasomes, the vesicular structures that mediate migracytosis. As migrating cells move, they leave long tubular strands, called retraction fibers, behind them. Large vesicles, which contain numerous smaller vesicles, grow on the tips and intersections of retraction fibers. These fibers, which connect the vesicles with the main cell body, eventually break, and the vesicles are released into the extracellular space or directly taken up by surrounding cells. Since the formation of these vesicles is migration-dependent, we named them “migrasomes”. We also found that cytosolic contents can be transported into migrasomes and released from the cell through migrasomes. We named this migration-dependent release mechanism “migracytosis”. Nature Publishing Group 2015-01 2014-10-24 /pmc/articles/PMC4650581/ /pubmed/25342562 http://dx.doi.org/10.1038/cr.2014.135 Text en Copyright © 2015 Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences http://creativecommons.org/licenses/by-nc-nd/3.0 This work is licensed under the Creative Commons Attribution-NonCommercial-No Derivative Works 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0 |
spellingShingle | Original Article Ma, Liang Li, Ying Peng, Junya Wu, Danni Zhao, Xiaoxin Cui, Yitong Chen, Lilian Yan, Xiaojun Du, Yanan Yu, Li Discovery of the migrasome, an organelle mediating release of cytoplasmic contents during cell migration |
title | Discovery of the migrasome, an organelle mediating release of cytoplasmic contents during cell migration |
title_full | Discovery of the migrasome, an organelle mediating release of cytoplasmic contents during cell migration |
title_fullStr | Discovery of the migrasome, an organelle mediating release of cytoplasmic contents during cell migration |
title_full_unstemmed | Discovery of the migrasome, an organelle mediating release of cytoplasmic contents during cell migration |
title_short | Discovery of the migrasome, an organelle mediating release of cytoplasmic contents during cell migration |
title_sort | discovery of the migrasome, an organelle mediating release of cytoplasmic contents during cell migration |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4650581/ https://www.ncbi.nlm.nih.gov/pubmed/25342562 http://dx.doi.org/10.1038/cr.2014.135 |
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