Cargando…

Discovery of the migrasome, an organelle mediating release of cytoplasmic contents during cell migration

Cells communicate with each other through secreting and releasing proteins and vesicles. Many cells can migrate. In this study, we report the discovery of migracytosis, a cell migration-dependent mechanism for releasing cellular contents, and migrasomes, the vesicular structures that mediate migracy...

Descripción completa

Detalles Bibliográficos
Autores principales: Ma, Liang, Li, Ying, Peng, Junya, Wu, Danni, Zhao, Xiaoxin, Cui, Yitong, Chen, Lilian, Yan, Xiaojun, Du, Yanan, Yu, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4650581/
https://www.ncbi.nlm.nih.gov/pubmed/25342562
http://dx.doi.org/10.1038/cr.2014.135
_version_ 1782401517922287616
author Ma, Liang
Li, Ying
Peng, Junya
Wu, Danni
Zhao, Xiaoxin
Cui, Yitong
Chen, Lilian
Yan, Xiaojun
Du, Yanan
Yu, Li
author_facet Ma, Liang
Li, Ying
Peng, Junya
Wu, Danni
Zhao, Xiaoxin
Cui, Yitong
Chen, Lilian
Yan, Xiaojun
Du, Yanan
Yu, Li
author_sort Ma, Liang
collection PubMed
description Cells communicate with each other through secreting and releasing proteins and vesicles. Many cells can migrate. In this study, we report the discovery of migracytosis, a cell migration-dependent mechanism for releasing cellular contents, and migrasomes, the vesicular structures that mediate migracytosis. As migrating cells move, they leave long tubular strands, called retraction fibers, behind them. Large vesicles, which contain numerous smaller vesicles, grow on the tips and intersections of retraction fibers. These fibers, which connect the vesicles with the main cell body, eventually break, and the vesicles are released into the extracellular space or directly taken up by surrounding cells. Since the formation of these vesicles is migration-dependent, we named them “migrasomes”. We also found that cytosolic contents can be transported into migrasomes and released from the cell through migrasomes. We named this migration-dependent release mechanism “migracytosis”.
format Online
Article
Text
id pubmed-4650581
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-46505812015-12-01 Discovery of the migrasome, an organelle mediating release of cytoplasmic contents during cell migration Ma, Liang Li, Ying Peng, Junya Wu, Danni Zhao, Xiaoxin Cui, Yitong Chen, Lilian Yan, Xiaojun Du, Yanan Yu, Li Cell Res Original Article Cells communicate with each other through secreting and releasing proteins and vesicles. Many cells can migrate. In this study, we report the discovery of migracytosis, a cell migration-dependent mechanism for releasing cellular contents, and migrasomes, the vesicular structures that mediate migracytosis. As migrating cells move, they leave long tubular strands, called retraction fibers, behind them. Large vesicles, which contain numerous smaller vesicles, grow on the tips and intersections of retraction fibers. These fibers, which connect the vesicles with the main cell body, eventually break, and the vesicles are released into the extracellular space or directly taken up by surrounding cells. Since the formation of these vesicles is migration-dependent, we named them “migrasomes”. We also found that cytosolic contents can be transported into migrasomes and released from the cell through migrasomes. We named this migration-dependent release mechanism “migracytosis”. Nature Publishing Group 2015-01 2014-10-24 /pmc/articles/PMC4650581/ /pubmed/25342562 http://dx.doi.org/10.1038/cr.2014.135 Text en Copyright © 2015 Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences http://creativecommons.org/licenses/by-nc-nd/3.0 This work is licensed under the Creative Commons Attribution-NonCommercial-No Derivative Works 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0
spellingShingle Original Article
Ma, Liang
Li, Ying
Peng, Junya
Wu, Danni
Zhao, Xiaoxin
Cui, Yitong
Chen, Lilian
Yan, Xiaojun
Du, Yanan
Yu, Li
Discovery of the migrasome, an organelle mediating release of cytoplasmic contents during cell migration
title Discovery of the migrasome, an organelle mediating release of cytoplasmic contents during cell migration
title_full Discovery of the migrasome, an organelle mediating release of cytoplasmic contents during cell migration
title_fullStr Discovery of the migrasome, an organelle mediating release of cytoplasmic contents during cell migration
title_full_unstemmed Discovery of the migrasome, an organelle mediating release of cytoplasmic contents during cell migration
title_short Discovery of the migrasome, an organelle mediating release of cytoplasmic contents during cell migration
title_sort discovery of the migrasome, an organelle mediating release of cytoplasmic contents during cell migration
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4650581/
https://www.ncbi.nlm.nih.gov/pubmed/25342562
http://dx.doi.org/10.1038/cr.2014.135
work_keys_str_mv AT maliang discoveryofthemigrasomeanorganellemediatingreleaseofcytoplasmiccontentsduringcellmigration
AT liying discoveryofthemigrasomeanorganellemediatingreleaseofcytoplasmiccontentsduringcellmigration
AT pengjunya discoveryofthemigrasomeanorganellemediatingreleaseofcytoplasmiccontentsduringcellmigration
AT wudanni discoveryofthemigrasomeanorganellemediatingreleaseofcytoplasmiccontentsduringcellmigration
AT zhaoxiaoxin discoveryofthemigrasomeanorganellemediatingreleaseofcytoplasmiccontentsduringcellmigration
AT cuiyitong discoveryofthemigrasomeanorganellemediatingreleaseofcytoplasmiccontentsduringcellmigration
AT chenlilian discoveryofthemigrasomeanorganellemediatingreleaseofcytoplasmiccontentsduringcellmigration
AT yanxiaojun discoveryofthemigrasomeanorganellemediatingreleaseofcytoplasmiccontentsduringcellmigration
AT duyanan discoveryofthemigrasomeanorganellemediatingreleaseofcytoplasmiccontentsduringcellmigration
AT yuli discoveryofthemigrasomeanorganellemediatingreleaseofcytoplasmiccontentsduringcellmigration