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Biological determinants of bladder cancer gene expression subtypes
Molecular stratification of tumors by gene expression profiling has been applied to a large number of human malignancies and holds great promise for personalized treatment. Comprehensive classification schemes for urothelial carcinoma have been proposed by three separate groups but have not previous...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4650643/ https://www.ncbi.nlm.nih.gov/pubmed/26051783 http://dx.doi.org/10.1038/srep10957 |
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author | Aine, Mattias Eriksson, Pontus Liedberg, Fredrik Sjödahl, Gottfrid Höglund, Mattias |
author_facet | Aine, Mattias Eriksson, Pontus Liedberg, Fredrik Sjödahl, Gottfrid Höglund, Mattias |
author_sort | Aine, Mattias |
collection | PubMed |
description | Molecular stratification of tumors by gene expression profiling has been applied to a large number of human malignancies and holds great promise for personalized treatment. Comprehensive classification schemes for urothelial carcinoma have been proposed by three separate groups but have not previously been evaluated simultaneously in independent data. Here we map the interrelations between the proposed molecular subtypes onto the intrinsic structure of a rich independent dataset and show that subtype stratification within each scheme can be explained in terms of a set of common underlying biological processes. We highlight novel biological and genomic drivers of urothelial carcinoma molecular subtypes and show that tumors carrying genomic aberrations characteristic of distinct molecular pathways converge on a common top level phenotype corresponding to the two major molecular subtypes of non-muscle invasive disease. |
format | Online Article Text |
id | pubmed-4650643 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-46506432015-11-24 Biological determinants of bladder cancer gene expression subtypes Aine, Mattias Eriksson, Pontus Liedberg, Fredrik Sjödahl, Gottfrid Höglund, Mattias Sci Rep Article Molecular stratification of tumors by gene expression profiling has been applied to a large number of human malignancies and holds great promise for personalized treatment. Comprehensive classification schemes for urothelial carcinoma have been proposed by three separate groups but have not previously been evaluated simultaneously in independent data. Here we map the interrelations between the proposed molecular subtypes onto the intrinsic structure of a rich independent dataset and show that subtype stratification within each scheme can be explained in terms of a set of common underlying biological processes. We highlight novel biological and genomic drivers of urothelial carcinoma molecular subtypes and show that tumors carrying genomic aberrations characteristic of distinct molecular pathways converge on a common top level phenotype corresponding to the two major molecular subtypes of non-muscle invasive disease. Nature Publishing Group 2015-06-08 /pmc/articles/PMC4650643/ /pubmed/26051783 http://dx.doi.org/10.1038/srep10957 Text en Copyright © 2015, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Aine, Mattias Eriksson, Pontus Liedberg, Fredrik Sjödahl, Gottfrid Höglund, Mattias Biological determinants of bladder cancer gene expression subtypes |
title | Biological determinants of bladder cancer gene expression subtypes |
title_full | Biological determinants of bladder cancer gene expression subtypes |
title_fullStr | Biological determinants of bladder cancer gene expression subtypes |
title_full_unstemmed | Biological determinants of bladder cancer gene expression subtypes |
title_short | Biological determinants of bladder cancer gene expression subtypes |
title_sort | biological determinants of bladder cancer gene expression subtypes |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4650643/ https://www.ncbi.nlm.nih.gov/pubmed/26051783 http://dx.doi.org/10.1038/srep10957 |
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